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http://hdl.handle.net/2445/126302
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DC Field | Value | Language |
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dc.contributor.author | Martínez Balibrea, Eva | - |
dc.contributor.author | Abad, Albert | - |
dc.contributor.author | Martínez Cardús, Anna | - |
dc.contributor.author | Ginés, A. | - |
dc.contributor.author | Valladares, M. | - |
dc.contributor.author | Navarro, M. | - |
dc.contributor.author | Aranda, Enrique | - |
dc.contributor.author | Marcuello, Eugenio | - |
dc.contributor.author | Benavides, M. | - |
dc.contributor.author | Massutí, B. | - |
dc.contributor.author | Carrato, A. | - |
dc.contributor.author | Layos, Laura | - |
dc.contributor.author | Manzano, José Luis | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.date.accessioned | 2018-11-21T15:07:29Z | - |
dc.date.available | 2018-11-21T15:07:29Z | - |
dc.date.issued | 2010-07-13 | - |
dc.identifier.issn | 0007-0920 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126302 | - |
dc.description.abstract | BACKGROUND: The impact of thymidylate synthase (TYMS) and UDP-glucoronosyltransferase 1A (UGT1A) germline polymorphisms on the outcome of colorectal cancer (CRC) patients treated with irinotecan plus 5-fluorouracil (irinotecan/5FU) is still controversial. Our objective was to define a genetic-based algorithm to select patients to be treated with irinotecan/5FU. METHODS: Genotyping of TYMS (5'TRP and 3'UTR), UGT1A1*28, UGT1A9*22 and UGT1A7*3 was performed in 149 metastatic CRC patients treated with irinotecan/5FU as first-line chemotherapy enrolled in a randomised phase 3 study. Their association with response, toxicity and survival was investigated by univariate and multivariate statistical analysis. RESULTS: TYMS 3TRP/3TRP genotype was the only independent predictor of tumour response (OR=5.87, 95% confidence interval (CI)=1.68-20.45; P=0.005). UGT1A1*28/*28 was predictive for haematologic toxicity (OR=6.27, 95% CI=1.09-36.12; P=0.04), specifically for neutropenia alone (OR=6.40, 95% CI=1.11-37.03; P=0.038) or together with diarrhoea (OR=18.87, 95% CI=2.14-166.67; P=0.008). UGT1A9*1/*1 was associated with non-haematologic toxicity (OR=2.70, 95% CI=1.07-6.82; P=0.035). Haplotype VII (all non-favourable alleles) was associated with non-haematologic toxicity (OR=2.11, 95% CI-1.12-3.98; P-0.02). CONCLUSION: TYMS and UGT1A polymorphisms influence on tumour response and toxicities derived from irinotecan/5FU treatment in CRC patients. A genetic-based algorithm to optimise treatment individualisation is proposed. British Journal of Cancer (2010) 103, 581-589. doi:10.1038/sj.bjc.6605776 www.bjcancer.com Published online 13 July 2010 (C) 2010 Cancer Research UK | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cancer Research UK | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/sj.bjc.6605776 | - |
dc.relation.ispartof | British Journal of Cancer, 2010, vol. 103, num. 4, p. 581-589 | - |
dc.relation.uri | https://doi.org/10.1038/sj.bjc.6605776 | - |
dc.rights | (c) Martinez Balibrea, E. et al., 2010 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Toxicitat dels medicaments | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Drug toxicity | - |
dc.title | UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 593134 | - |
dc.date.updated | 2018-11-21T15:07:29Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 20628391 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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593134.pdf | 442.51 kB | Adobe PDF | View/Open |
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