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http://hdl.handle.net/2445/126331
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DC Field | Value | Language |
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dc.contributor.author | Wolpin, Brian M. | - |
dc.contributor.author | Rizzato, Cosmeri | - |
dc.contributor.author | Kraft, Peter | - |
dc.contributor.author | Kooperberg, Charles | - |
dc.contributor.author | Petersen, Gloria M. | - |
dc.contributor.author | Wang, Zhaoming | - |
dc.contributor.author | Arslan, Alan A. | - |
dc.contributor.author | Beane Freeman, Laura | - |
dc.contributor.author | Bracci, Paige M. | - |
dc.contributor.author | Buring, Julie E. | - |
dc.contributor.author | Canzian, Federico | - |
dc.contributor.author | Albanes, Demetrius | - |
dc.contributor.author | Andreotti, Gabriella | - |
dc.contributor.author | Bugert, Peter | - |
dc.contributor.author | Austin, Melissa A. | - |
dc.contributor.author | Barfield, Richard T. | - |
dc.contributor.author | Basso, Daniela | - |
dc.contributor.author | Capurso, Gabriele | - |
dc.contributor.author | Berndt, Sonja I. | - |
dc.contributor.author | Brotzman, Michelle | - |
dc.contributor.author | Büchler, Markus W. | - |
dc.contributor.author | Costello, Eithne | - |
dc.contributor.author | Bueno de Mesquita, H. Bas | - |
dc.contributor.author | Burdette, Laurie | - |
dc.contributor.author | Campa, Daniele | - |
dc.contributor.author | Caporaso, Neil E. | - |
dc.contributor.author | Chung, Charles C. | - |
dc.contributor.author | Giovannucci, Edward L. | - |
dc.contributor.author | Cotterchio, Michelle | - |
dc.contributor.author | Elena, Joanne W. | - |
dc.contributor.author | Hassan, Manal | - |
dc.contributor.author | Funel, Niccola | - |
dc.contributor.author | Gaziano, J. Michael M. | - |
dc.contributor.author | Giese, Nathalia A. | - |
dc.contributor.author | Hu, Nan | - |
dc.contributor.author | Goggins, Michael | - |
dc.contributor.author | Gorman, Megan J | - |
dc.contributor.author | Gross, Myron D. | - |
dc.contributor.author | Jenab, Mazda | - |
dc.contributor.author | Haiman, Christopher A. | - |
dc.contributor.author | Helzlsouer, Kathy J. | - |
dc.contributor.author | Henderson, Brian E. | - |
dc.contributor.author | Holly, Elizabeth A. | - |
dc.contributor.author | Hunter, David J. | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.contributor.author | Innocenti, Federico | - |
dc.contributor.author | Kaaks, Rudolf | - |
dc.contributor.author | Landi, Maria Teresa | - |
dc.contributor.author | Key, Timothy J. | - |
dc.contributor.author | Khaw, Kay-Tee | - |
dc.contributor.author | Klein, Eric A. | - |
dc.contributor.author | Mannisto, Satu | - |
dc.contributor.author | Krogh, Vittorio | - |
dc.contributor.author | Kupcinskas, Juozas | - |
dc.contributor.author | Kurtz, Robert C. | - |
dc.contributor.author | Oberg, Ann L. | - |
dc.contributor.author | LaCroix, Andrea | - |
dc.contributor.author | Landi, Stefano | - |
dc.contributor.author | Marchand, Loïc Le | - |
dc.contributor.author | Mambrini, Andrea | - |
dc.contributor.author | Peters, Ulrike | - |
dc.contributor.author | Milne, Roger L. | - |
dc.contributor.author | Nakamura, Yusuke | - |
dc.contributor.author | Owzar, Kouros | - |
dc.contributor.author | Rothman, Nathaniel | - |
dc.contributor.author | Patel, Alpa V. | - |
dc.contributor.author | Peeters, Petra H. M. | - |
dc.contributor.author | Pezzilli, Raffaele | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | Piepoli, Ada | - |
dc.contributor.author | Porta, Miquel, 1957- | - |
dc.contributor.author | Real, Francisco X. | - |
dc.contributor.author | Taylor, Philip R. | - |
dc.contributor.author | Riboli, Elio | - |
dc.contributor.author | Scarpa, Aldo | - |
dc.contributor.author | Shu, Xiao-Ou | - |
dc.contributor.author | Silverman, Debra T. | - |
dc.contributor.author | Soucek, Pavel | - |
dc.contributor.author | Sund, Malin | - |
dc.contributor.author | Talar-Wojnarowska, Renata | - |
dc.contributor.author | Theodoropoulos, George E. | - |
dc.contributor.author | Yu, Herbert | - |
dc.contributor.author | Thornquist, Mark D. | - |
dc.contributor.author | Tobias, Geoffrey S. | - |
dc.contributor.author | Trichopoulos, Dimitrios | - |
dc.contributor.author | Hoover, Robert N. | - |
dc.contributor.author | Vodicka, Pavel | - |
dc.contributor.author | Wactawski-Wende, Jean | - |
dc.contributor.author | Wentzensen, Nicolas | - |
dc.contributor.author | Stolzenberg-Solomon, Rachael Z. | - |
dc.contributor.author | Wu, Chen | - |
dc.contributor.author | Yu, Kai | - |
dc.contributor.author | Zeleniuch-Jacquotte, Anne | - |
dc.contributor.author | Duell, Eric J. | - |
dc.contributor.author | Hartge, Patricia | - |
dc.contributor.author | Fuchs, Charles S. | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Amundadottir, Laufey | - |
dc.contributor.author | Kolonel, Laurence N. | - |
dc.contributor.author | Gallinger, Steven | - |
dc.contributor.author | Giles, Graham G. | - |
dc.contributor.author | Goodman, Gary E. | - |
dc.contributor.author | Olson, Sara H. | - |
dc.contributor.author | Goodman, Phyllis J. | - |
dc.contributor.author | Jacobs, Eric J. | - |
dc.contributor.author | Kamineni, Aruna | - |
dc.contributor.author | White, Emily | - |
dc.contributor.author | Klein, Alison P. | - |
dc.contributor.author | Kulke, Matthew H. | - |
dc.contributor.author | Li, Donghui | - |
dc.contributor.author | Malats, Núria | - |
dc.contributor.author | Risch, Harvey A. | - |
dc.contributor.author | Sesso, Howard D. | - |
dc.contributor.author | Visvanathan, Kala | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Boutron-Ruault, Marie-Christine | - |
dc.contributor.author | Abnet, Christian C. | - |
dc.date.accessioned | 2018-11-22T11:29:24Z | - |
dc.date.available | 2018-11-22T11:29:24Z | - |
dc.date.issued | 2014-09-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126331 | - |
dc.description.abstract | We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 x 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 x 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 x 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 x 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 x 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 x 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies. | - |
dc.format.extent | 27 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/ng.3052 | - |
dc.relation.ispartof | Nature Genetics, 2014, vol. 46, num. 9, p. 994-1000 | - |
dc.relation.uri | https://doi.org/10.1038/ng.3052 | - |
dc.rights | (c) Wolpin et al., 2014 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Genòmica | - |
dc.subject.classification | Càncer de pàncrees | - |
dc.subject.other | Genomics | - |
dc.subject.other | Pancreas cancer | - |
dc.title | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2018-07-24T12:38:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25086665 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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WolpinBM.pdf | 2.12 MB | Adobe PDF | View/Open |
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