Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126405
Title: | PK/PD models in antibacterial development |
Author: | Velkov, Tony Bergen, Phillip J. Lora-Tamayo Morillo-Velarde, Jaime Landersdorfer, Cornelia B. Li, Jian |
Keywords: | Medicaments antibacterians Antibiòtics Antibacterial agents Antibiotics |
Issue Date: | Oct-2013 |
Publisher: | Elsevier |
Abstract: | There is an urgent need for novel antibiotics to treat life-threatening infections caused by bacterial 'superbugs'. Validated in vitro pharmacokinetic/pharmacodynamic (PK/PD) and animal infection models have been employed to identify the most predictive PK/PD indices and serve as key tools in the antibiotic development process. The results obtained can be utilized for optimizing study designs in order to minimize the cost and duration of clinical trials. This review outlines the key in vitro PK/PD and animal infection models which have been extensively used in antibiotic discovery and development. These models have shown great potential in accelerating drug development programs and will continue to make significant contributions to antibiotic development. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.mib.2013.06.010 |
It is part of: | Current Opinion in Microbiology, 2013, vol. 16, num. 5, p. 573-579 |
URI: | http://hdl.handle.net/2445/126405 |
Related resource: | https://doi.org/10.1016/j.mib.2013.06.010 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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VelkovT.pdf | 299.52 kB | Adobe PDF | View/Open |
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