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Title: | Allelic and genotypic associations of DRD2 Taq I A polymorphism with heroin dependence in Spanish subjects: a case control study |
Author: | Pérez de los Cobos Peris, José C. Baiget Bastús, Montserrat Trujols i Albet, Joan Sinol, Nuria Volpini Bertrán, Víctor Banuls, Enrique Calafell, Francesc Luquero, Elena Rio, Elisabeth del Alvarez, Enric |
Keywords: | Heroïna Metadona Heroin Methadone hydrochloride |
Issue Date: | 1-Jun-2007 |
Publisher: | BioMed Central |
Abstract: | Background: Conflicting associations with heroin dependence have been found involving the A1 allele of dopamine D2 receptor gene ( DRD2) TaqI A polymorphism. Methods: We compared two samples of unrelated Spanish individuals, all of European origin: 281 methadone-maintained heroin-dependent patients ( 207 males and 74 females) who frequently used non-opioid substances, and 145 control subjects ( 98 males and 47 females). Results: The A1-A1 genotype was detected in 7.1% of patients and 1.4% of controls ( P = 0.011, odds ratio = 5.48, 95% CI 1.26-23.78). Although the A1 allele was not associated with heroin dependence in the entire sample, the frequency of A1 allele was higher in male patients than in male controls ( 24.4% vs. 16.3%, P = 0.024, odds ratio = 1.65, 95% CI 1.07-2.57). A logistic regression analysis showed an interaction between DRD2 alleles and gender ( odds ratio = 1.77, 95% CI 1.15-2.70). Conclusion: Our results indicate that, in Spanish individuals, genotypes of the DRD2 TaqI A polymorphism contribute to variations in the risk of heroin dependence, while single alleles contribute only in males. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/1744-9081-3-25 |
It is part of: | Behavioral and Brain Functions, 2007, vol. 3, num. 25 |
URI: | http://hdl.handle.net/2445/126407 |
Related resource: | https://doi.org/10.1186/1744-9081-3-25 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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de los CobosJP.pdf | 228.38 kB | Adobe PDF | View/Open |
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