Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126428
Title: | Human papillomavirus is not associated with colorectal cancer in a large international study |
Author: | Gornick, Michele C. Castellsagué, Xavier Sánchez, Gloria Giordano, Thomas J. Vinco, Michelle Greenson, Joel K. Capellá, G. (Gabriel) Raskin, Leon Rennert, Gad Gruber, Stephen B. Moreno Aguado, Víctor |
Keywords: | Papil·lomavirus Càncer colorectal Papillomaviruses Colorectal cancer |
Issue Date: | May-2010 |
Publisher: | Springer Verlag |
Abstract: | Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer. The GP5+/GP6+ PCR reverse line blot method was used for detection of 37 types of human papillomavirus (HPV) in DNA from paraffin-embedded or frozen tissues from patients with colorectal cancer (n = 279) and normal adjacent tissue (n = 30) in three different study populations, including samples from the United States (n = 73), Israel (n = 106) and Spain (n = 100). Additionally, SPF10 PCR was run on all samples (n = 279) and the Innogenetics INNO-LiPA assay was performed on a subset of samples (n = 15). All samples were negative for all types of HPV using both the GP5+/GP6+ PCR reverse line blot method and the SPF10 INNO-LiPA method. We conclude that HPV types associated with malignant transformation do not meaningfully contribute to adenocarcinoma of the colon. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1007/s10552-010-9502-0 |
It is part of: | Cancer Causes & Control, 2010, vol. 21, num. 5, p. 737-743 |
URI: | http://hdl.handle.net/2445/126428 |
Related resource: | https://doi.org/10.1007/s10552-010-9502-0 |
ISSN: | 0957-5243 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
593131.pdf | 154.11 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.