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http://hdl.handle.net/2445/126439
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DC Field | Value | Language |
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dc.contributor.author | Klein, Alison P. | - |
dc.contributor.author | Lindström, Sara | - |
dc.contributor.author | Mendelsohn, Julie B. | - |
dc.contributor.author | Steplowski, Emily | - |
dc.contributor.author | Arslan, Alan A. | - |
dc.contributor.author | Bueno de Mesquita, H. Bas | - |
dc.contributor.author | Fuchs, Charles S. | - |
dc.contributor.author | Gallinger, Steven | - |
dc.contributor.author | Gross, Myron D. | - |
dc.contributor.author | Helzlsouer, Kathy J. | - |
dc.contributor.author | Holly, Elizabeth A. | - |
dc.contributor.author | Jacobs, Eric J. | - |
dc.contributor.author | LaCroix, Andrea | - |
dc.contributor.author | Li, Donghui | - |
dc.contributor.author | Mandelson, Margaret T. | - |
dc.contributor.author | Olson, Sara H. | - |
dc.contributor.author | Petersen, Gloria M. | - |
dc.contributor.author | Risch, Harvey A. | - |
dc.contributor.author | Stolzenberg-Solomon, Rachael Z. | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Amundadottir, Laufey | - |
dc.contributor.author | Albanes, Demetrius | - |
dc.contributor.author | Allen, Naomi E. | - |
dc.contributor.author | Bamlet, William R. | - |
dc.contributor.author | Boutron-Ruault, Marie-Christine | - |
dc.contributor.author | Buring, Julie E. | - |
dc.contributor.author | Bracci, Paige M. | - |
dc.contributor.author | Canzian, Federico | - |
dc.contributor.author | Clipp, Sandra | - |
dc.contributor.author | Cotterchio, Michelle | - |
dc.contributor.author | Duell, Eric J. | - |
dc.contributor.author | Elena, Joanne W. | - |
dc.contributor.author | Gaziano, J. Michael M. | - |
dc.contributor.author | Giovannucci, Edward L. | - |
dc.contributor.author | Goggins, Michael | - |
dc.contributor.author | Hallmans, Göran | - |
dc.contributor.author | Hassan, Manal | - |
dc.contributor.author | Hutchinson, Amy | - |
dc.contributor.author | Hunter, David J. | - |
dc.contributor.author | Kooperberg, Charles | - |
dc.contributor.author | Kurtz, Robert C. | - |
dc.contributor.author | Liu, Simin | - |
dc.contributor.author | Overvad, Kim | - |
dc.contributor.author | Palli, Domenico | - |
dc.contributor.author | Patel, Alpa V. | - |
dc.contributor.author | Rabe, Kari G. | - |
dc.contributor.author | Shu, Xiao-Ou | - |
dc.contributor.author | Slimani, Nadia | - |
dc.contributor.author | Tobias, Geoffrey S. | - |
dc.contributor.author | Trichopoulos, Dimitrios | - |
dc.contributor.author | Van Den Eeden, Stephen K. | - |
dc.contributor.author | Vineis, Paolo | - |
dc.contributor.author | Virtamo, Jarmo | - |
dc.contributor.author | Wactawski-Wende, Jean | - |
dc.contributor.author | Wolpin, Brian M. | - |
dc.contributor.author | Yu, Herbert | - |
dc.contributor.author | Yu, Kai | - |
dc.contributor.author | Zeleniuch-Jacquotte, Anne | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Hoover, Robert N. | - |
dc.contributor.author | Hartge, Patricia | - |
dc.contributor.author | Kraft, Peter | - |
dc.date.accessioned | 2018-11-26T14:22:29Z | - |
dc.date.available | 2018-11-26T14:22:29Z | - |
dc.date.issued | 2013-09-13 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126439 | - |
dc.description.abstract | Purpose: We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer. Patients and Methods: Using data on 3,349 cases and 3,654 controls from the PanScan Consortium, we developed a relative risk model for men and women of European ancestry based on non-genetic and genetic risk factors for pancreatic cancer. We estimated absolute risks based on these relative risks and population incidence rates. Results: Our risk model included current smoking (multivariable adjusted odds ratio (OR) and 95% confidence interval: 2.20 [1.84-2.62]), heavy alcohol use (>3 drinks/day) (OR: 1.45 [1.19-1.76]), obesity (body mass index >30 kg/m(2)) (OR: 1.26 [1.09-1.45]), diabetes >3 years (nested case-control OR: 1.57 [1.13-2.18], case-control OR: 1.80 [1.40-2.32]), family history of pancreatic cancer (OR: 1.60 [1.20-2.12]), non-O ABO genotype (AO vs. OO genotype) (OR: 1.23 [1.10-1.37]) to (BB vs. OO genotype) (OR 1.58 [0.97-2.59]), rs3790844(chr1q32.1) (OR: 1.29 [1.19-1.40]), rs401681(5p15.33) (OR: 1.18 [1.10-1.26]) and rs9543325(13q22.1) (OR: 1.27 [1.18-1.36]). The areas under the ROC curve for risk models including only non-genetic factors, only genetic factors, and both non-genetic and genetic factors were 58%, 57% and 61%, respectively. We estimate that fewer than 3/1,000 U. S. non-Hispanic whites have more than a 5% predicted lifetime absolute risk. Conclusion: Although absolute risk modeling using established risk factors may help to identify a group of individuals at higher than average risk of pancreatic cancer, the immediate clinical utility of our model is limited. However, a risk model can increase awareness of the various risk factors for pancreatic cancer, including modifiable behaviors. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0072311 | - |
dc.relation.ispartof | PLoS One, 2013, vol. 8, num. 9, p. e72311 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0072311 | - |
dc.rights | cc by (c) Klein et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de pàncrees | - |
dc.subject.classification | Diabetis | - |
dc.subject.other | Pancreas cancer | - |
dc.subject.other | Diabetes | - |
dc.title | An Absolute Risk Model to Identify Individuals at Elevated Risk for Pancreatic Cancer in the General Population | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:45:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24058443 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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