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http://hdl.handle.net/2445/126454
Title: | Angiotensinogen Promoter Polymorphisms Predict Low Diffusing Capacity in U.S. and Spanish IPF Cohorts |
Author: | Dang, My-Trang T. Gu, Chenyang Klavanian, Jeannie I. Jernigan, Katherine A. Friderici, Karen H. Cui, Yuehua Molina Molina, María Ancochea Bermúdez, Julio Xaubet Mir, Antonio Uhal, Bruce D. |
Keywords: | Angiogènesi Malalties del pulmó Neovascularization Pulmonary diseases |
Issue Date: | Aug-2013 |
Publisher: | Springer |
Abstract: | Single nucleotide polymorphisms (SNPs) in angiotensinogen (AGT) at positions -20 and -6 are associated with increased severity and progression of various fibrotic diseases. Our earlier work demonstrated that the progression of idiopathic pulmonary fibrosis (IPF) was associated with the A-6 allele. This study examined the hypothesis that the homozygous CC genotype at -20 and the AA genotype at -6 would confer worse measures of pulmonary function (measured by pulmonary function tests) in IPF. Multiple logistic regression analysis was applied to a NIH Lung Tissue Research Consortium cohort and a Spanish cohort, while also adjusting for covariates to determine the effects of these SNPs on measures of pulmonary function. Analysis demonstrated that the CC genotype at -20 was strongly associated with reduced diffusing capacity in males in both cohorts (p = 0.0028 for LTRC and p = 0.017 for the Spanish cohort). In females, the AA genotype was significantly associated with lower FVC (p = 0.0082) and V (alv) (p = 0.022). In males, the haplotype CA at -20 and -6 in AGT was also strongly associated with reduced diffusing capacity in both cohorts. This study is the first to demonstrate an association of AGT polymorphisms (-20A > C and -6G > A) with lower measures of pulmonary function in IPF. It is also the first to relate the effect of gender in lung fibrosis with polymorphisms in AGT. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1007/s00408-013-9476-2 |
It is part of: | Lung, 2013, vol. 191, num. 4, p. 353-360 |
URI: | http://hdl.handle.net/2445/126454 |
Related resource: | https://doi.org/10.1007/s00408-013-9476-2 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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