Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126515
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Martínez Poveda, Beatriz | - |
dc.contributor.author | Rodríguez Nieto, Salvador | - |
dc.contributor.author | García Caballero, Melissa | - |
dc.contributor.author | Medina, Miguel Ángel | - |
dc.contributor.author | Quesada, Ana R. | - |
dc.date.accessioned | 2018-11-28T09:04:22Z | - |
dc.date.available | 2018-11-28T09:04:22Z | - |
dc.date.issued | 2012-09-18 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126515 | - |
dc.description.abstract | Aeroplysinin-1 is a brominated metabolite extracted from the marine sponge Aplysina aerophoba that has been previously characterized by our group as a potent antiangiogenic compound in vitro and in vivo. In this work, we provide evidence of a selective induction of apoptosis by aeroplysinin-1 in endothelial cells. Studies on the nuclear morphology of treated cells revealed that aeroplysinin-1 induces chromatin condensation and nuclear fragmentation, and it increases the percentage of cells with sub-diploid DNA content in endothelial, but not in HCT-116, human colon carcinoma and HT-1080 human fibrosarcoma cells. Treatment of endothelial cells with aeroplysinin-1 induces activation of caspases-2, -3, -8 and -9, as well as the cleavage of apoptotic substrates, such as poly (ADP-ribose) polymerase and lamin-A in a caspase-dependent mechanism. Our data indicate a relevant role of the mitochondria in the apoptogenic activity of this compound. The observation that aeroplysinin-1 prevents the phosphorylation of Bad relates to the mitochondria-mediated induction of apoptosis by this compound. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/md10092033 | - |
dc.relation.ispartof | Marine Drugs, 2012, vol. 10, num. 9, p. 2033-2046 | - |
dc.relation.uri | https://doi.org/10.3390/md10092033 | - |
dc.rights | cc by (c) Martínez Poveda et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Angiogènesi | - |
dc.subject.classification | Apoptosi | - |
dc.subject.other | Neovascularization | - |
dc.subject.other | Apoptosis | - |
dc.title | The Antiangiogenic Compound Aeroplysinin-1 Induces Apoptosis in Endothelial Cells by Activating the Mitochondrial Pathway | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:53:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23118719 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Martinez-PovedaB.pdf | 551.35 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License