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DC Field | Value | Language |
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dc.contributor.author | Jacobs, Kevin B. | - |
dc.contributor.author | Yeager, Meredith | - |
dc.contributor.author | Zhou, Weiyin | - |
dc.contributor.author | Wacholder, Sholom | - |
dc.contributor.author | Wang, Zhaoming | - |
dc.contributor.author | Rodríguez Santiago, Benjamín | - |
dc.contributor.author | Hutchinson, Amy | - |
dc.contributor.author | Deng, Xiang | - |
dc.contributor.author | Liu, Chenwei | - |
dc.contributor.author | Horner, Marie-Josephe | - |
dc.contributor.author | Cullen, Michael | - |
dc.contributor.author | Bertazzi, Pier Alberto | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Erickson, Ralph L. | - |
dc.contributor.author | Gorlick, Richard G. | - |
dc.contributor.author | Elena, Joanne W. | - |
dc.contributor.author | Visvanathan, Kala | - |
dc.contributor.author | Bueno de Mesquita, H. Bas | - |
dc.contributor.author | Tobias, Geoffrey S. | - |
dc.contributor.author | Marenne, Gaelle | - |
dc.contributor.author | Marchand, Loïc Le | - |
dc.contributor.author | Pérez Jurado, Luis | - |
dc.contributor.author | Petersen, Gloria M. | - |
dc.contributor.author | Rothman, Nathaniel | - |
dc.contributor.author | Chung, Charles C. | - |
dc.contributor.author | McWilliams, Robert R. | - |
dc.contributor.author | Kovaks, Joseph | - |
dc.contributor.author | Rajaraman, Preetha | - |
dc.contributor.author | Amundadottir, Laufey | - |
dc.contributor.author | Rotunno, Melissa | - |
dc.contributor.author | Carreon, Tania | - |
dc.contributor.author | Chatterjee, Nilanjan | - |
dc.contributor.author | Berg, Christine D. | - |
dc.contributor.author | Goldin, Lynn R. | - |
dc.contributor.author | Inskip, Peter D. | - |
dc.contributor.author | Barkauskas, Donald A. | - |
dc.contributor.author | Dean, Michael C. | - |
dc.contributor.author | Feychting, Maria | - |
dc.contributor.author | Taylor, Philip R. | - |
dc.contributor.author | Wu, Xifeng | - |
dc.contributor.author | Andersson, Ulrika | - |
dc.contributor.author | Virtamo, Jarmo | - |
dc.contributor.author | Gillanders, Elizabeth M. | - |
dc.contributor.author | Malats, Núria | - |
dc.contributor.author | Davis, Faith G. | - |
dc.contributor.author | Black, Amanda | - |
dc.contributor.author | Haiman, Christopher A. | - |
dc.contributor.author | Dean, Michael C. | - |
dc.contributor.author | Melin, Beatrice S. | - |
dc.contributor.author | Goldstein, Alisa M. | - |
dc.contributor.author | Hunter, David J. | - |
dc.contributor.author | Freedman, Neal D. | - |
dc.contributor.author | Liao, Linda | - |
dc.contributor.author | Boutron-Ruault, Marie-Christine | - |
dc.contributor.author | Hoffman Bolton, Judith A. | - |
dc.contributor.author | Berndt, Sonja I. | - |
dc.contributor.author | Rybicki, Benjamin A. | - |
dc.contributor.author | LaCroix, Andrea | - |
dc.contributor.author | Rabe, Kari G. | - |
dc.contributor.author | Hankinson, Susan E. | - |
dc.contributor.author | Baris, Dalsu | - |
dc.contributor.author | Figueroa, Jonine D. | - |
dc.contributor.author | Bracci, Paige M. | - |
dc.contributor.author | Severi, Gianluca | - |
dc.contributor.author | McKean-Cowdin, Roberta | - |
dc.contributor.author | Koh, Woon-Puay | - |
dc.contributor.author | Weinstein, Stephanie J. | - |
dc.contributor.author | Mandelson, Margaret T. | - |
dc.contributor.author | Gao, Yu-Tang | - |
dc.contributor.author | Spitz, Margaret R. | - |
dc.contributor.author | Schwartz, Ann G. | - |
dc.contributor.author | Yu, Kai | - |
dc.contributor.author | Kolonel, Laurence N. | - |
dc.contributor.author | Hartge, Patricia | - |
dc.contributor.author | Harris, Curtis C. | - |
dc.contributor.author | Teras, Lauren R. | - |
dc.contributor.author | Buring, Julie E. | - |
dc.contributor.author | Fraumeni Jr., Joseph F. | - |
dc.contributor.author | McGlynn, Katherine A. | - |
dc.contributor.author | Yuan, Jian-Min | - |
dc.contributor.author | Greene, Mark H. | - |
dc.contributor.author | Sesso, Howard D. | - |
dc.contributor.author | Riboli, Elio | - |
dc.contributor.author | Mirabello, Lisa | - |
dc.contributor.author | Schwartz, Kendra L. | - |
dc.contributor.author | Jiao, Li | - |
dc.contributor.author | Risch, Harvey A. | - |
dc.contributor.author | Wolk, Alicja | - |
dc.contributor.author | Hsing, Ann W. | - |
dc.contributor.author | Abnet, Christian C. | - |
dc.contributor.author | McNeill, Lorna H. | - |
dc.contributor.author | Prokunina-Olsson, Ludmila | - |
dc.contributor.author | Wolpin, Brian M. | - |
dc.contributor.author | Garcia Closas, Montserrat | - |
dc.contributor.author | Michaud, Dominique S. | - |
dc.contributor.author | Gaziano, J. Michael M. | - |
dc.contributor.author | Li, Donghui | - |
dc.contributor.author | Johansen, Christoffer | - |
dc.contributor.author | Ziegler, Regina G. | - |
dc.contributor.author | Stevens, Victoria L. | - |
dc.contributor.author | Signorello, Lisa B. | - |
dc.contributor.author | Tucker, Margaret | - |
dc.contributor.author | Ding, Ti | - |
dc.contributor.author | Landgren, Annelie | - |
dc.contributor.author | Aldrich, Melinda C. | - |
dc.contributor.author | Stram, Daniel | - |
dc.contributor.author | Henriksson, Roger | - |
dc.contributor.author | Kraft, Peter | - |
dc.contributor.author | Henderson, Brian E. | - |
dc.contributor.author | Stolzenberg-Solomon, Rachael Z. | - |
dc.contributor.author | Hu, Nan | - |
dc.contributor.author | Schwenn, Molly | - |
dc.contributor.author | Xiang, Yong-Bing | - |
dc.contributor.author | Gross, Myron D. | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.contributor.author | Bock, Cathryn H. | - |
dc.contributor.author | Epstein, Caroline G. | - |
dc.contributor.author | Purdue, Mark P. | - |
dc.contributor.author | Qiao, You-Lin | - |
dc.contributor.author | Patiño García, Ana | - |
dc.contributor.author | Kooperberg, Charles | - |
dc.contributor.author | Canzian, Federico | - |
dc.contributor.author | Ahlbom, Anders | - |
dc.contributor.author | Khaw, Kay-Tee | - |
dc.contributor.author | Hassan, Manal | - |
dc.contributor.author | Villa, Olaya | - |
dc.contributor.author | Giovannucci, Edward L. | - |
dc.contributor.author | Shu, Xiao-Ou | - |
dc.contributor.author | Gaudet, Mia M. | - |
dc.contributor.author | Klein, Alison P. | - |
dc.contributor.author | Cook, Michael B. | - |
dc.contributor.author | Ruder, Avima M. | - |
dc.contributor.author | Zeleniuch-Jacquotte, Anne | - |
dc.contributor.author | Chatterjee, Nilanjan | - |
dc.contributor.author | Goggins, Michael | - |
dc.contributor.author | Chang, Kenneth | - |
dc.contributor.author | Wiencke, John K. | - |
dc.contributor.author | Gapstur, Susan M. | - |
dc.contributor.author | Real, Francisco X. | - |
dc.contributor.author | Zanetti, Krista A. | - |
dc.contributor.author | Wunder, Jay S. | - |
dc.contributor.author | Wheeler, William | - |
dc.contributor.author | Schumacher, Fredrick | - |
dc.contributor.author | Gonzalez, Juan R. | - |
dc.contributor.author | Gallinger, Steven | - |
dc.contributor.author | Fan, Jin-Hu | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Peplonska, Beata | - |
dc.contributor.author | Landi, Maria Teresa | - |
dc.contributor.author | Thomas, Gilles | - |
dc.contributor.author | Wrensch, Margaret | - |
dc.contributor.author | Savage, Sharon A. | - |
dc.contributor.author | Silverman, Debra T. | - |
dc.contributor.author | Wentzensen, Nicolas | - |
dc.contributor.author | Giles, Graham G. | - |
dc.contributor.author | Andrulis, Irene L. | - |
dc.contributor.author | Amos, Christopher I. | - |
dc.contributor.author | Cotterchio, Michelle | - |
dc.contributor.author | Tang, Ze-Zhong | - |
dc.contributor.author | Sierrasesúmaga, Luis | - |
dc.contributor.author | Consonni, Dario | - |
dc.contributor.author | Kurtz, Robert C. | - |
dc.contributor.author | Albanes, Demetrius | - |
dc.contributor.author | Burdett, Laurie | - |
dc.contributor.author | Trichopoulos, Dimitrios | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | Olson, Sara H. | - |
dc.contributor.author | Chow, Wong-Ho | - |
dc.contributor.author | Johnson, Alison | - |
dc.contributor.author | Krogh, Vittorio | - |
dc.contributor.author | Butler, Mary A. | - |
dc.contributor.author | Beane Freeman, Laura | - |
dc.contributor.author | White, Emily | - |
dc.contributor.author | Kratz, Christian P. | - |
dc.contributor.author | Graubard, Barry I. | - |
dc.contributor.author | Holly, Elizabeth A. | - |
dc.contributor.author | Blot, William J. | - |
dc.contributor.author | Arslan, Alan A. | - |
dc.contributor.author | Hallmans, Göran | - |
dc.contributor.author | Fuchs, Charles S. | - |
dc.contributor.author | Sampson, Joshua N. | - |
dc.contributor.author | Peters, Ulrike | - |
dc.contributor.author | Duell, Eric J. | - |
dc.contributor.author | Brinton, Louise A. | - |
dc.contributor.author | Jenab, Mazda | - |
dc.contributor.author | Yu, Herbert | - |
dc.contributor.author | Hoover, Robert N. | - |
dc.contributor.author | Kovaks, Joseph | - |
dc.contributor.author | Caporaso, Neil E. | - |
dc.contributor.author | Lissowska, Jolanta | - |
dc.contributor.author | Moore, Lee E. | - |
dc.contributor.author | Mendelsohn, Julie B. | - |
dc.date.accessioned | 2018-11-28T09:38:33Z | - |
dc.date.available | 2018-11-28T09:38:33Z | - |
dc.date.issued | 2012-05-06 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126522 | - |
dc.description.abstract | In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of > 2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 x 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 x 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/ng.2270 | - |
dc.relation.ispartof | Nature Genetics, 2012, vol. 44, num. 6, p. 651-U68 | - |
dc.relation.uri | https://doi.org/10.1038/ng.2270 | - |
dc.rights | (c) Jacobs et al., 2012 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Envelliment | - |
dc.subject.other | Cancer | - |
dc.subject.other | Aging | - |
dc.title | Detectable clonal mosaicism and its relationship to aging and cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2018-07-24T12:54:42Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/201663/EU//UROMOL | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22561519 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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JacobsKB.pdf | 789.83 kB | Adobe PDF | View/Open |
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