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DC Field | Value | Language |
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dc.contributor.author | Ibáñez, Raquel | - |
dc.contributor.author | Moreno Crespi, Judit | - |
dc.contributor.author | Sardà, Montserrat | - |
dc.contributor.author | Autonell, Josefina | - |
dc.contributor.author | Fibla, Montserrat | - |
dc.contributor.author | Gutiérrez Miguélez, Cristina | - |
dc.contributor.author | Lloveras Rubio, Betlem | - |
dc.contributor.author | Alejo, Maria | - |
dc.contributor.author | Català, Isabel | - |
dc.contributor.author | Alameda, Francesc | - |
dc.contributor.author | Casas, Miquel | - |
dc.contributor.author | Bosch José, Francesc Xavier, 1947- | - |
dc.contributor.author | Sanjosé Llongueras, Silvia de | - |
dc.date.accessioned | 2018-11-28T10:28:28Z | - |
dc.date.available | 2018-11-28T10:28:28Z | - |
dc.date.issued | 2012-01-26 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126534 | - |
dc.description.abstract | Background: A protocol for cervical cancer screening among sexually active women 25 to 65 years of age was introduced in 2006 in Catalonia, Spain to increase coverage and to recommend a 3-year-interval between screening cytology. In addition, Human Papillomavirus (HPV) was offered as a triage test for women with a diagnosis of atypical squamous cells of undetermined significance (ASC-US). HPV testing was recommended within 3 months of ASC-US diagnosis. According to protocol, HPV negative women were referred to regular screening including a cytological exam every 3 years while HPV positive women were referred to colposcopy and closer follow-up. We evaluated the implementation of the protocol and the prediction of HPV testing as a triage tool for cervical intraepithelial lesions grade two or worse (CIN2+) in women with a cytological diagnosis of ASC-US. Methods: During 2007-08 a total of 611 women from five reference laboratories in Catalonia with a novel diagnosis of ASC-US were referred for high risk HPV (hrHPV) triage using high risk Hybrid Capture version 2. Using routine record linkage data, women were followed for 3 years to evaluate hrHPV testing efficacy for predicting CIN2+ cases. Logistic regression analysis was used to estimate the odds ratio for CIN2 +. Results: Among the 611 women diagnosed with ASC-US, 493 (80.7%) had at least one follow-up visit during the study period. hrHPV was detected in 48.3% of the women at study entry (mean age 35.2 years). hrHPV positivity decreased with increasing age from 72.6% among women younger than 25 years to 31.6% in women older than 54 years (p < 0.01). At the end of the 3 years follow-up period, 37 women with a diagnosis of CIN2+ (18 CIN2, 16 CIN3, 2 cancers, and 1 with high squamous intraepithelial lesions -HSIL) were identified and all but one had a hrHPV positive test at study entry. Sensitivity to detect CIN2+ of hrHPV was 97.2% (95%confidence interval (CI) = 85.5-99.9) and specificity was 68.3% (95%CI = 63.1-73.2). The odds ratio for CIN2+ was 45.3 (95% CI: 6.2-333.0), when among ASC-US hrHPV positive women were compared to ASC-US hrHPV negative women. Conclusions: Triage of ASC-US with hrHPV testing showed a high sensitivity for the detection of CIN2+ and a high negative predictive value after 3 years of follow-up. The results of this study are in line with the current guidelines for triage of women with ASC-US in the target age range of 25-65. Non adherence to guidelines will lead to unnecessary medical interventions. Further investigation is needed to improve specificity of ASC-US triage. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/1471-2334-12-25 | - |
dc.relation.ispartof | BMC Infectious Diseases, 2012, vol. 12, num. 25 | - |
dc.relation.uri | https://doi.org/10.1186/1471-2334-12-25 | - |
dc.rights | cc by (c) Ibáñez et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de coll uterí | - |
dc.subject.classification | Papil·lomavirus | - |
dc.subject.other | Cervix cancer | - |
dc.subject.other | Papillomaviruses | - |
dc.title | Prediction of cervical intraepithelial neoplasia grade 2+ (CIN2+) using HPV DNA testing after a diagnosis of atypical squamous cell of undetermined significance (ASC-US) in Catalonia, Spain | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:56:44Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/242061/EU//PREHDICT | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22280073 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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