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DC Field | Value | Language |
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dc.contributor.author | Díaz Ramos, M. Àngels | - |
dc.contributor.author | Roig Borrellas, Anna | - |
dc.contributor.author | García Melero, Ana | - |
dc.contributor.author | López Alemany, Roser | - |
dc.date.accessioned | 2018-11-29T09:12:02Z | - |
dc.date.available | 2018-11-29T09:12:02Z | - |
dc.date.issued | 2012-01-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126560 | - |
dc.description.abstract | α-Enolase is a key glycolytic enzyme in the cytoplasm of prokaryotic and eukaryotic cells and is considered a multifunctional protein. α-enolase is expressed on the surface of several cell types, where it acts as a plasminogen receptor, concentrating proteolytic plasmin activity on the cell surface. In addition to glycolytic enzyme and plasminogen receptor functions, α-Enolase appears to have other cellular functions and subcellular localizations that are distinct from its well-established function in glycolysis. Furthermore, differential expression of α-enolase has been related to several pathologies, such as cancer, Alzheimer’s disease, and rheumatoid arthritis, among others. We have identified α-enolase as a plasminogen receptor in several cell types. In particular, we have analyzed its role in myogenesis, as an example of extracellular remodelling process. We have shown that α-enolase is expressed on the cell surface of differentiating myocytes, and that inhibitors of α-enolase/plasminogen binding block myogenic fusion in vitro and skeletal muscle regeneration in mice. α-Enolase could be considered as a marker of pathological stress in a high number of diseases, performing several of its multiple functions, mainly as plasminogen receptor. This paper is focused on the multiple roles of the α-enolase/plasminogen axis, related to several pathologies. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Hindawi Publishing Corporation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1155/2012/156795 | - |
dc.relation.ispartof | Journal of Biomedicine and Biotechnology, 2012, vol. 2012 | - |
dc.relation.uri | https://doi.org/10.1155/2012/156795 | - |
dc.rights | cc by (c) Díaz Ramos et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Hidrolases | - |
dc.subject.classification | Glucòlisi | - |
dc.subject.other | Proteins | - |
dc.subject.other | Hydrolases | - |
dc.subject.other | Glycolysis | - |
dc.title | α-Enolase, a Multifunctional Protein: Its Role on Pathophysiological Situations | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:57:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23118496 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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Diaz-RamosA.pdf | 749.94 kB | Adobe PDF | View/Open |
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