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http://hdl.handle.net/2445/126610
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DC Field | Value | Language |
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dc.contributor.author | Incoronato, Mariarosaria | - |
dc.contributor.author | Urso, Loredana | - |
dc.contributor.author | Portela, Anna | - |
dc.contributor.author | Laukkanen, Mikko O. | - |
dc.contributor.author | Soini, Ylermi | - |
dc.contributor.author | Quintavalle, Ylermi | - |
dc.contributor.author | Keller, Simona | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Condorelli, Gerolama | - |
dc.date.accessioned | 2018-11-30T09:45:06Z | - |
dc.date.available | 2018-11-30T09:45:06Z | - |
dc.date.issued | 2011-11-15 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126610 | - |
dc.description.abstract | Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0027722 | - |
dc.relation.ispartof | PLoS One, 2011, vol. 6, num. 11, p. e27722 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0027722 | - |
dc.rights | cc by (c) Incoronato et al., 2011 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | ADN | - |
dc.subject.classification | Càncer de pulmó | - |
dc.subject.other | DNA | - |
dc.subject.other | Lung cancer | - |
dc.title | Epigenetic Regulation of miR-212 Expression in Lung Cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 700256 | - |
dc.date.updated | 2018-07-24T12:58:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22110741 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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IncoronatoM.pdf | 248.13 kB | Adobe PDF | View/Open |
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