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Title: | Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-κB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility |
Author: | Diéguez González, Rebeca Calaza, Manuel Perez-Pampin, Eva Balsa, Alejandro Blanco, Francisco J. Cañete Crespillo, Juan D. Caliz, Rafael Carreño, Luis Serna, Arturo R. de la Fernández Gutiérrez, Benjamín Ortiz, Ana María Herrero-Beaumont, Gabriel Pablos, José L. Narváez García, Francisco Javier Navarro Sarabia, Federico Marenco de la Fuente, José Luis Gomez Reino, Juan J. Gonzalez, Antonio |
Keywords: | Artritis reumatoide Lupus eritematós Rheumatoid arthritis Lupus erythematosus |
Issue Date: | 17-Mar-2009 |
Publisher: | BioMed Central |
Abstract: | Introduction Genome-wide association studies of rheumatoid arthritis (RA) have identified an association of the disease with a 6q23 region devoid of genes. TNFAIP3, an RA candidate gene, flanks this region, and polymorphisms in both the TNFAIP3 gene and the intergenic region are associated with systemic lupus erythematosus. We hypothesized that there is a similar association with RA, including polymorphisms in TNFAIP3 and the intergenic region. Methods To test this hypothesis, we selected tag-single nucleotide polymorphisms (SNPs) in both loci. They were analyzed in 1,651 patients with RA and 1,619 control individuals of Spanish ancestry. Results Weak evidence of association was found both in the 6q23 intergenic region and in the TNFAIP3 locus. The rs582757 SNP and a common haplotype in the TNFAIP3 locus exhibited association with RA. In the intergenic region, two SNPs were associated, namely rs609438 and rs13207033. The latter was only associated in patients with anti-citrullinated peptide antibodies. Overall, statistical association was best explained by the interdependent contribution of SNPs from the two loci TNFAIP3 and the 6q23 intergenic region. Conclusions Our data are consistent with the hypothesis that several RA genetic factors exist in the 6q23 region, including polymorphisms in the TNFAIP3 gene, like that previously described for systemic lupus erythematosus. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/ar2650 |
It is part of: | Arthritis Research & Therapy, 2009, vol. 11, num.R42 |
URI: | http://hdl.handle.net/2445/126635 |
Related resource: | https://doi.org/10.1186/ar2650 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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