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http://hdl.handle.net/2445/126747
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DC Field | Value | Language |
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dc.contributor.author | Alcalde Cabero, Enrique | - |
dc.contributor.author | Almazan Isla, Javier | - |
dc.contributor.author | García López, Fernando J. | - |
dc.contributor.author | Ara Callizo, José Ramón | - |
dc.contributor.author | Avellanal, Fuencisla | - |
dc.contributor.author | Casasnovas Pons, Carlos | - |
dc.contributor.author | Cemillán, Carlos | - |
dc.contributor.author | Cuadrado, José Ignacio | - |
dc.contributor.author | Duarte, Jacinto | - |
dc.contributor.author | Fernández Pérez, María Dolores | - |
dc.contributor.author | Fernández, Óscar | - |
dc.contributor.author | García Merino, Juan Antonio | - |
dc.contributor.author | García Montero, Rosa | - |
dc.contributor.author | Montero, Dolores | - |
dc.contributor.author | Pardo, Julio | - |
dc.contributor.author | Rodríguez Rivera, Francisco Javier | - |
dc.contributor.author | Ruiz Tovar, María | - |
dc.contributor.author | Pedro Cuesta, Jesús de | - |
dc.contributor.author | Spanish GBS Epidemiology Study Group | - |
dc.date.accessioned | 2018-12-05T11:48:59Z | - |
dc.date.available | 2018-12-05T11:48:59Z | - |
dc.date.issued | 2016-05-21 | - |
dc.identifier.issn | 1471-2377 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126747 | - |
dc.description.abstract | Background: Studies have shown a slight excess risk in Guillain-Barre syndrome (GBS) incidence associated with A(H1N1) pdm09 vaccination campaign and seasonal trivalent influenza vaccine immunisations in 2009-2010. We aimed to assess the incidence of GBS as a potential adverse effect of A(H1N1) pdm09 vaccination. Methods: A neurologist-led network, active at the neurology departments of ten general hospitals serving an adult population of 4.68 million, conducted GBS surveillance in Spain in 2009-2011. The network, established in 1996, carried out a retrospective and a prospective study to estimate monthly alarm thresholds in GBS incidence and tested them in 1998-1999 in a pilot study. Such incidence thresholds additionally to observation of GBS cases with immunisation antecedent in the 42 days prior to clinical onset were taken as alarm signals for 2009-2011, since November 2009 onwards. For purpose of surveillance, in 2009 we updated both the available centres and the populations served by the network. We also did a retrospective countrywide review of hospital-discharged patients having ICD-9-CM code 357.0 (acute infective polyneuritis) as their principal diagnosis from January 2009 to December 2011. Results: Among 141 confirmed of 148 notified cases of GBS or Miller-Fisher syndrome, Brighton 1-2 criteria in 96 %, not a single patient was identified with clinical onset during the 42-day time interval following A(H1N1) pdm09 vaccination. In contrast, seven cases were seen during a similar period after seasonal campaigns. Monthly incidence figures did not, however, exceed the upper 95 % CI limit of expected incidence. A retrospective countrywide review of the registry of hospital-discharged patients having ICD-9-CM code 357.0 (acute infective polyneuritis) as their principal diagnosis did not suggest higher admission rates in critical months across the period December 2009-February 2010. Conclusions: Despite limited power and underlying reporting bias in 2010-2011, an increase in GBS incidence over background GBS, associated with A(H1N1) pdm09 monovalent or trivalent influenza immunisations, appears unlikely. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12883-016-0598-z | - |
dc.relation.ispartof | BMC Neurology, 2016, vol. 16, p. 75 | - |
dc.relation.uri | https://doi.org/10.1186/s12883-016-0598-z | - |
dc.rights | cc-by (c) Alcalde Cabero, Enrique et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.classification | Nervis perifèrics | - |
dc.subject.classification | Influenzavirus | - |
dc.subject.classification | Grip | - |
dc.subject.classification | Vacunes | - |
dc.subject.other | Autoimmune diseases | - |
dc.subject.other | Peripheral nerves | - |
dc.subject.other | Influenza viruses | - |
dc.subject.other | Influenza | - |
dc.subject.other | Vaccines | - |
dc.title | Guillain-Barré syndrome following the 2009 pandemic monovalent and seasonal trivalent influenza vaccination campaigns in Spain from 2009 to 2011: outcomes from active surveillance by a neurologist network, and records from a country-wide hospital discharge database | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 677732 | - |
dc.date.updated | 2018-12-05T11:48:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27206524 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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