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Title: | A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium |
Author: | McKay, James D. Truong, Thérèse Gaborieau, Valérie Chabrier, Amélie Chuang, Shu-Chun Byrnes, Graham Zaridze, David Shangina, Oxana Szeszenia-Dabrowska, Neonila Lissowska, Jolanta Rudnai, Peter Manni, Johannes J. Toner, Mary E. Znaor, Ariana McClean, Michael D. Curado, Maria Paula Bueno de Mesquita, H. Bas Koifman, Sergio Menezes, Ana A. Oszutowska, Dorota Fernández Garrote, Leticia Hallmans, Göran Boccia, Stefania Olshan, Andrew F. Doody, David R. Weissler, Mark C. Funkhouser, William K. Lubinski, Jan Gallagher, Carla J. Trubicka, Joanna Lener, Marcin Schwartz, Stephen M. Wei, Qingyi Chen, Chu Fish, Sherianne Muscat, Joshua E. Lazarus, Philip Marsit, Carmen J. Chang, Shen-Chih Buch, Shama Zhang, Zuo-Feng Sturgis, Erich M. Peters, Wilbert H. M. Wang, Li-E Bencko, Vladimir Franceschi, Silvia Herrero, Rolando Vatten, Lars Kelsey, Karl T. Lagiou, Pagona Nelson, Heather H. Nukui, Tomoko Liloglou, Triantafillos Zhong, Shilong Lacko, Martin Khaw, Kay-Tee Key, Timothy J. Hung, Rayjean J. McLaughlin, John R. Njølstad, Inger Panico, Salvatore Goodman, Gary E. Field, John K. Vineis, Paolo Clavel-Chapelon, Françoise Palli, Domenico Tumino, Rosario Peeters, Petra H. M. Krogh, Vittorio González, Carlos A. Overvad, Kim Quirós, J. Ramón Merletti, Franco Martínez, Carmen Navarro, Carmen Riboli, Elio Ardanaz, Eva Cadoni, Gabriella Larrañaga, Nerea Trichopoulou, Antonia Zelenika, Diana Linseisen, Jakob Boeing, Heiner Tjønneland, Anne Lechner, Doris Fabianova, Eleonora Kumle, Merethe Välk, Kristjan Gut, Ivo G. Voodern, Tõnu Metspalu, Andres Boland, Anne Delepine, Marc Foglio, Mario Bucur, Alexandru Holcátová, Ivana Blanché, Hélène Galan, Pilar Trichopoulos, Dimitrios Heath, Simon C. Luo, Jingchun Hashibe, Mia Hayes, Richard B. Richiardi, Lorenzo Boffetta, Paolo Romkes, Marjorie Lathrop, Mark Brennan, Paul MacFarlane, Gary J. Janout, Vladimir Foretova, Lenka Benhamou, Simone Agudo, Antonio Bouchardy, Christine Ahrens, Wolfgang Talamini, Renato Conway, David I. Barzan, Luigi Kjaerheim, Kristina MacFarlane, Tatiana V. Simonato, Lorenzo Canova, Cristina Castellsagué, Xavier Neto, José Eluf Lowry, Ray McKinney, Patricia A. Arzani, Dario Healy, Claire M. |
Keywords: | Consum d'alcohol Càncer Genètica Drinking of alcoholic beverages Cancer Genetics |
Issue Date: | 17-Mar-2011 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p <= 5 x 10(-7)). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1 x 10(-8)) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2 x 10(-8)) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5 x 10(-8); rs1229984-ADH1B, p = 7 x 10(-9); and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pgen.1001333 |
It is part of: | PLoS Genetics, 2011, vol. 7, num. 3, p. e1001333 |
URI: | http://hdl.handle.net/2445/126770 |
Related resource: | https://doi.org/10.1371/journal.pgen.1001333 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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