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Title: Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
Author: Fages, Anne
Duarte Salles, Talita
Stepien, Magdalena
Ferrari, Pietro
Fedirko, Veronika
Pontoizeau, Clément
Trichopoulou, Antonia
Aleksandrova, Krasimira
Tjønneland, Anne
Olsen, Anja
Clavel-Chapelon, Françoise
Boutron-Ruault, Marie-Christine
Severi, Gianluca
Kaaks, Rudolf
Kuhn, Tilman
Floegel, Anna
Boeing, Heiner
Lagiou, Pagona
Bamia, Christina
Trichopoulos, Dimitrios
Palli, Domenico
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Vineis, Paolo
Bueno de Mesquita, H. Bas
Peeters, Petra H. M.
Weiderpass, Elisabete
Agudo, Antonio
Molina Montes, Esther
Huerta Castaño, José María
Ardanaz, Eva
Dorronsoro, Miren
Sjöberg, Klas
Ohlsson, Bodil
Khaw, Kay-Tee
Wareham, Nicholas J.
Travis, Ruth C.
Schmidt, Julie A.
Cross, Amanda J.
Gunter, Marc J.
Riboli, Elio
Scalbert, Augustin
Romieu, Isabelle
Elena-Herrmann, Benedicte
Jenab, Mazda
Keywords: Epidemiologia
Càncer de fetge
Liver cancer
Issue Date: 23-Sep-2015
Publisher: BioMed Central
Abstract: Background: Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers. Methods: To address these aspects, an untargeted nuclear magnetic resonance metabolomic approach was applied to pre-diagnostic serum samples obtained from first incident, primary HCC cases (n = 114) and matched controls (n = 222) identified from amongst the participants of a large European prospective cohort. Results: A metabolic pattern associated with HCC risk comprised of perturbations in fatty acid oxidation and amino acid, lipid, and carbohydrate metabolism was observed. Sixteen metabolites of either endogenous or exogenous origin were found to be significantly associated with HCC risk. The influence of hepatitis infection and potential liver damage was assessed, and further analyses were made to distinguish patterns of early or later diagnosis. Conclusion: Our results show clear metabolic alterations from early stages of HCC development with application for better etiologic understanding, prevention, and early detection of this increasingly common cancer.
Note: Reproducció del document publicat a:
It is part of: BMC Medicine, 2015, vol. 13, num. 242
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Publicacions de projectes de recerca finançats per la UE

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