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Title: | Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort |
Author: | Fages, Anne Duarte Salles, Talita Stepien, Magdalena Ferrari, Pietro Fedirko, Veronika Pontoizeau, Clément Trichopoulou, Antonia Aleksandrova, Krasimira Tjønneland, Anne Olsen, Anja Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Severi, Gianluca Kaaks, Rudolf Kuhn, Tilman Floegel, Anna Boeing, Heiner Lagiou, Pagona Bamia, Christina Trichopoulos, Dimitrios Palli, Domenico Pala, Valeria Panico, Salvatore Tumino, Rosario Vineis, Paolo Bueno de Mesquita, H. Bas Peeters, Petra H. M. Weiderpass, Elisabete Agudo, Antonio Molina Montes, Esther Huerta Castaño, José María Ardanaz, Eva Dorronsoro, Miren Sjöberg, Klas Ohlsson, Bodil Khaw, Kay-Tee Wareham, Nicholas J. Travis, Ruth C. Schmidt, Julie A. Cross, Amanda J. Gunter, Marc J. Riboli, Elio Scalbert, Augustin Romieu, Isabelle Elena-Herrmann, Benedicte Jenab, Mazda |
Keywords: | Epidemiologia Càncer de fetge Epidemiology Liver cancer |
Issue Date: | 23-Sep-2015 |
Publisher: | BioMed Central |
Abstract: | Background: Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of early risk biomarkers. Methods: To address these aspects, an untargeted nuclear magnetic resonance metabolomic approach was applied to pre-diagnostic serum samples obtained from first incident, primary HCC cases (n = 114) and matched controls (n = 222) identified from amongst the participants of a large European prospective cohort. Results: A metabolic pattern associated with HCC risk comprised of perturbations in fatty acid oxidation and amino acid, lipid, and carbohydrate metabolism was observed. Sixteen metabolites of either endogenous or exogenous origin were found to be significantly associated with HCC risk. The influence of hepatitis infection and potential liver damage was assessed, and further analyses were made to distinguish patterns of early or later diagnosis. Conclusion: Our results show clear metabolic alterations from early stages of HCC development with application for better etiologic understanding, prevention, and early detection of this increasingly common cancer. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s12916-015-0462-9 |
It is part of: | BMC Medicine, 2015, vol. 13, num. 242 |
URI: | http://hdl.handle.net/2445/126856 |
Related resource: | https://doi.org/10.1186/s12916-015-0462-9 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
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