Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126861
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Couch, Fergus J. | - |
dc.contributor.author | Kuchenbaecker, Karoline B. | - |
dc.contributor.author | Michailidou, Kyriaki | - |
dc.contributor.author | Mendoza-Fandino, Gustavo A. | - |
dc.contributor.author | Nord, Silje | - |
dc.contributor.author | Lilyquist, Jenna | - |
dc.contributor.author | Olswold, Curtis | - |
dc.contributor.author | Hallberg, Emily | - |
dc.contributor.author | Agata, Simona | - |
dc.contributor.author | Ahsan, Habibul | - |
dc.contributor.author | Aittomäki, Kristiina | - |
dc.contributor.author | Flesch-Janys, Dieter | - |
dc.contributor.author | Carpenter, Jane | - |
dc.contributor.author | Tomlinson, Ian P. | - |
dc.contributor.author | James, Paul | - |
dc.contributor.author | Tollenaar, Raem | - |
dc.contributor.author | Swerdlow, Anthony J. | - |
dc.contributor.author | Bojesen, Stig E. | - |
dc.contributor.author | McGuffog, Lesley | - |
dc.contributor.author | Miron, Penelope | - |
dc.contributor.author | Truong, Thérèse | - |
dc.contributor.author | Toland, Amanda Ewart | - |
dc.contributor.author | Henderson, Brian E. | - |
dc.contributor.author | Hollestelle, Antoinette | - |
dc.contributor.author | Knight, Julia A. | - |
dc.contributor.author | Cox, Angela | - |
dc.contributor.author | Burwinkel, Barbara | - |
dc.contributor.author | Yang, Xiaohong R | - |
dc.contributor.author | Yannoukakos, Drakoulis | - |
dc.contributor.author | Varon-Mateeva, Raymonda | - |
dc.contributor.author | Lázaro García, Conxi | - |
dc.contributor.author | Hooning, Maartje J. | - |
dc.contributor.author | Rutgers, Emiel J. | - |
dc.contributor.author | Domchek, Susan M. | - |
dc.contributor.author | Wang-Gohrke, Shan | - |
dc.contributor.author | Lambrechts, Diether | - |
dc.contributor.author | Wang, Zhaoming | - |
dc.contributor.author | Tsimiklis, Helen | - |
dc.contributor.author | Daly, Mary B. | - |
dc.contributor.author | Arver, Brita | - |
dc.contributor.author | Olah, Edith | - |
dc.contributor.author | Sawyer, Elinor J. | - |
dc.contributor.author | Khaw, Kay-Tee | - |
dc.contributor.author | Long, Jirong | - |
dc.contributor.author | Eccles, Diana | - |
dc.contributor.author | Díez Gibert, Orland | - |
dc.contributor.author | Chenevix-Trench, Georgia | - |
dc.contributor.author | Pharoah, Paul D. P. | - |
dc.contributor.author | Yao, Song | - |
dc.contributor.author | Margolin, Sara | - |
dc.contributor.author | Kibriya, Muhammad G. | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Manoukian, Siranoush | - |
dc.contributor.author | Zamora, M. Pilar | - |
dc.contributor.author | Blank, Stephanie V. | - |
dc.contributor.author | Ambrosone, Christine | - |
dc.contributor.author | Chang-Claude, Jenny | - |
dc.contributor.author | Phelan, Catherine M. | - |
dc.contributor.author | Szabo, Csilla I. | - |
dc.contributor.author | Barrowdale, Daniel | - |
dc.contributor.author | Frost, Debra | - |
dc.contributor.author | Bolla, Manjeet K. | - |
dc.contributor.author | Bonanni, Bernardo | - |
dc.contributor.author | Hunter, David J. | - |
dc.contributor.author | Nathanson, Katherine L. | - |
dc.contributor.author | Liu, Jianjun | - |
dc.contributor.author | García Closas, Montserrat | - |
dc.contributor.author | Muranen, Taru A. | - |
dc.contributor.author | Monteiro, Alvaro N. | - |
dc.contributor.author | Buys, Saundra S. | - |
dc.contributor.author | Dorfling, Cecilia M. | - |
dc.contributor.author | Teulé-Vega, Àlex | - |
dc.contributor.author | Claes, Kathleen B. M. | - |
dc.contributor.author | Glendon, Gord | - |
dc.contributor.author | Damiola, Francesca | - |
dc.contributor.author | Darabi, Hatef | - |
dc.contributor.author | Kosma, Veli-Matti | - |
dc.contributor.author | Park, Sue K. | - |
dc.contributor.author | Brenner, Hermann | - |
dc.contributor.author | Osorio, Ana | - |
dc.contributor.author | Brauch, Hiltrud | - |
dc.contributor.author | Rudolph, Anja | - |
dc.contributor.author | Weitzel, Jeffrey N. | - |
dc.contributor.author | Dunning, Alison M. | - |
dc.contributor.author | Haeberle, Lothar | - |
dc.contributor.author | Eliassen, Heather | - |
dc.contributor.author | Ellis, Steve | - |
dc.contributor.author | Pylkäs, Katri | - |
dc.contributor.author | Devilee, Peter | - |
dc.contributor.author | Poppe, Bruce | - |
dc.contributor.author | Hoya, Miguel de la | - |
dc.contributor.author | Blomqvist, Carl | - |
dc.contributor.author | Jakubowska, Anna | - |
dc.contributor.author | Herzog, Josef | - |
dc.contributor.author | Ganz, Patricia A. | - |
dc.contributor.author | Gapstur, Susan M. | - |
dc.contributor.author | Figueroa, Jonine D. | - |
dc.contributor.author | Scott, Rodney J. | - |
dc.contributor.author | Fasching, Peter A. | - |
dc.contributor.author | Cunningham, Julie M. | - |
dc.contributor.author | Arun, Banu K. | - |
dc.contributor.author | Ko, Yon-Dschun | - |
dc.contributor.author | Fostira, Florentia | - |
dc.contributor.author | Schmutzler, Rita Katharina | - |
dc.contributor.author | Försti, Asta | - |
dc.contributor.author | Santos-Silva, Isabel dos | - |
dc.contributor.author | John, Esther M. | - |
dc.contributor.author | van Rensburg, Elizabeth J. | - |
dc.contributor.author | Weiderpass, Elisabete | - |
dc.contributor.author | Foulkes, William D. | - |
dc.contributor.author | Barkardottir, Rosa B. | - |
dc.contributor.author | Robson, Mark | - |
dc.contributor.author | Steinemann, Doris | - |
dc.contributor.author | Laitman, Yael | - |
dc.contributor.author | Khan, Sofia | - |
dc.contributor.author | Goldgar, David E. | - |
dc.contributor.author | González Neira, Anna | - |
dc.contributor.author | Gaudet, Mia M. | - |
dc.contributor.author | Teo, Soo-Hwang | - |
dc.contributor.author | Romieu, Isabelle | - |
dc.contributor.author | Lubinski, Jan | - |
dc.contributor.author | Gerdes, Anne-Marie | - |
dc.contributor.author | Teixeira, Manuel R. | - |
dc.contributor.author | Gayther, Simon A. | - |
dc.contributor.author | Friebel, Tara M. | - |
dc.contributor.author | Lee, Eunjung | - |
dc.contributor.author | Humphreys, Keith | - |
dc.contributor.author | Hall, Peter | - |
dc.contributor.author | Chung, Wendy K. | - |
dc.contributor.author | Beckmann, Matthias W. | - |
dc.contributor.author | Mannermaa, Arto | - |
dc.contributor.author | Lindström, Sara | - |
dc.contributor.author | Hansen, Thomas V. O. | - |
dc.contributor.author | Hart, Steven | - |
dc.contributor.author | Greene, Mark H. | - |
dc.contributor.author | Turnbull, Clare | - |
dc.contributor.author | Southey, Melissa C. | - |
dc.contributor.author | Guénel, Pascal | - |
dc.contributor.author | Tung, Nadine | - |
dc.contributor.author | Gronwald, Jacek | - |
dc.contributor.author | Hogervorst, Frans B. L. | - |
dc.contributor.author | Konstantopoulou, Irene | - |
dc.contributor.author | Easton, Douglas F. | - |
dc.contributor.author | Dumont, Martine | - |
dc.contributor.author | Imyanitov, Evgeny N. | - |
dc.contributor.author | Mulligan, Anna Marie | - |
dc.contributor.author | Jones, Michael | - |
dc.contributor.author | Kabisch, Maria | - |
dc.contributor.author | Santella, Regina M. | - |
dc.contributor.author | Winqvist, Robert | - |
dc.contributor.author | Heikkinen, Tuomas | - |
dc.contributor.author | Wildiers, Hans | - |
dc.contributor.author | Healey, Sue | - |
dc.contributor.author | Andrulis, Irene L. | - |
dc.contributor.author | Arndt, Volker | - |
dc.contributor.author | Friedman, Eitan | - |
dc.contributor.author | Kwong, Ava | - |
dc.contributor.author | Olson, Janet E. | - |
dc.contributor.author | Marchand, Loïc Le | - |
dc.contributor.author | Lester, Jenny | - |
dc.contributor.author | Slager, Susan L. | - |
dc.contributor.author | Karlan, Beth Y. | - |
dc.contributor.author | Vachon, Celine M. | - |
dc.contributor.author | Kar, Siddhartha P. | - |
dc.contributor.author | Canzian, Federico | - |
dc.contributor.author | Giles, Graham G. | - |
dc.contributor.author | Malone, Kathleen E. | - |
dc.contributor.author | Pilarski, Robert | - |
dc.contributor.author | Marmé, Frederik | - |
dc.contributor.author | Martens, John W. M. | - |
dc.contributor.author | Lindor, Noralane | - |
dc.contributor.author | Bogdanova, Natalia V. | - |
dc.contributor.author | Lindblom, Annika | - |
dc.contributor.author | Janavicius, Ramunas | - |
dc.contributor.author | Schmidt, Marjanka K. | - |
dc.contributor.author | Rennert, Gad | - |
dc.contributor.author | Neuhausen, Susan L. | - |
dc.contributor.author | Nevanlinna, Heli | - |
dc.contributor.author | Meindl, Alfons | - |
dc.contributor.author | Czene, Kamila | - |
dc.contributor.author | Anton-Culver, Hoda | - |
dc.contributor.author | Hopper, John L. | - |
dc.contributor.author | Stenmark-Askmalm, Marie | - |
dc.contributor.author | Milne, Roger L. | - |
dc.contributor.author | Cross, Simon S. | - |
dc.contributor.author | Miller, Austin | - |
dc.contributor.author | Mai, Phuong L. | - |
dc.contributor.author | Senter, Leigha | - |
dc.contributor.author | Garber, Judy | - |
dc.contributor.author | Ghoussaini, Maya | - |
dc.contributor.author | Huzarski, Tomasz | - |
dc.contributor.author | Caldes, Trinidad | - |
dc.contributor.author | Dolcetti, Riccardo | - |
dc.contributor.author | Tapper, William | - |
dc.contributor.author | Soucy, Penny | - |
dc.contributor.author | Peeters, Petra H. M. | - |
dc.contributor.author | Peissel, Bernard | - |
dc.contributor.author | Nordestgaard, Børge G. | - |
dc.contributor.author | Ekici, Arif B. | - |
dc.contributor.author | Caligo, Maria A. | - |
dc.contributor.author | Offit, Kenneth | - |
dc.contributor.author | Ehrencrona, Hans | - |
dc.contributor.author | Nussbaum, Robert L. | - |
dc.contributor.author | Montagna, Marco | - |
dc.contributor.author | Beckmann, Lars | - |
dc.contributor.author | Sánchez, María José | - |
dc.contributor.author | Gunter, Marc J. | - |
dc.contributor.author | Kristensen, Vessela N. | - |
dc.contributor.author | Isaacs, Claudine | - |
dc.contributor.author | Tumino, Rosario | - |
dc.contributor.author | Radice, Paolo | - |
dc.contributor.author | Rahman, Nazneen | - |
dc.contributor.author | Barile, Monica | - |
dc.contributor.author | Gammon, Marilie D. | - |
dc.contributor.author | Ding, Yuan C. | - |
dc.contributor.author | Peto, Julian | - |
dc.contributor.author | Gabrielson, Marike | - |
dc.contributor.author | Peterlongo, Paolo | - |
dc.contributor.author | Richardson, Andrea | - |
dc.contributor.author | Stoppa-Lyonnet, Dominique | - |
dc.contributor.author | Makalic, Enes | - |
dc.contributor.author | Schmidt, Daniel F. | - |
dc.contributor.author | Whittemore, Alice | - |
dc.contributor.author | Sharma, Priyanka | - |
dc.contributor.author | Simard, Jacques | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Goldberg, Mark S. | - |
dc.contributor.author | Rappaport-Fuerhauser, Christine | - |
dc.contributor.author | Godwin, Andrew K. | - |
dc.contributor.author | Rantala, Johanna | - |
dc.contributor.author | Hoover, Robert N. | - |
dc.contributor.author | Mazoyer, Sylvie | - |
dc.contributor.author | Tamimi, Rulla | - |
dc.contributor.author | Kraft, Peter | - |
dc.contributor.author | Terry, Mary Beth | - |
dc.contributor.author | Thomassen, Mads | - |
dc.contributor.author | Hamann, Ute | - |
dc.contributor.author | Sinilnikova, Olga M. | - |
dc.contributor.author | Haiman, Christopher A. | - |
dc.contributor.author | Singer, Christian F. | - |
dc.contributor.author | Olopade, Olufunmilayo I. | - |
dc.contributor.author | Benitez, Javier | - |
dc.contributor.author | Antoniou, Antonis C. | - |
dc.contributor.author | Ursin, Giski | - |
dc.contributor.author | van Deurzen, Carolien H. M. | - |
dc.contributor.author | Tihomirova, Laima | - |
dc.contributor.author | Jensen, Uffe Birk | - |
dc.contributor.author | Thompson, Deborah J. | - |
dc.contributor.author | Schumacher, Fredrick | - |
dc.date.accessioned | 2018-12-11T07:22:43Z | - |
dc.date.available | 2018-12-11T07:22:43Z | - |
dc.date.issued | 2016-04-27 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126861 | - |
dc.description.abstract | Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 x 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for similar to 11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/ncomms11375 | - |
dc.relation.ispartof | Nature Communications, 2016, vol. 7 | - |
dc.relation.uri | https://doi.org/10.1038/ncomms11375 | - |
dc.rights | cc by (c) Couch et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de mama | - |
dc.title | Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-25T07:50:38Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/223175/EU//COGS | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27117709 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
CouchFJ.pdf | 1.01 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License