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http://hdl.handle.net/2445/126869
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DC Field | Value | Language |
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dc.contributor.author | Sánchez Velázquez, Patricia | - |
dc.contributor.author | Castellví, Quim | - |
dc.contributor.author | Villanueva Garatachea, Alberto | - |
dc.contributor.author | Quesada, Rita | - |
dc.contributor.author | Pañella, Clara | - |
dc.contributor.author | Cáceres, M. | - |
dc.contributor.author | Dorcaratto, D. | - |
dc.contributor.author | Andaluz, Anna | - |
dc.contributor.author | Moll, Xavier | - |
dc.contributor.author | Trujillo, M. | - |
dc.contributor.author | Burdío, J. M. | - |
dc.contributor.author | Berjano, E. | - |
dc.contributor.author | Grande, L. | - |
dc.contributor.author | Ivorra, Antoni | - |
dc.contributor.author | Burdío, Fernando | - |
dc.date.accessioned | 2018-12-11T10:22:33Z | - |
dc.date.available | 2018-12-11T10:22:33Z | - |
dc.date.issued | 2016-04-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126869 | - |
dc.description.abstract | Irreversible electroporation is a fast-growing liver ablation technique. Although safety has been well documented in small ablations, our aim is to assess its safety and feasibility when a large portion of liver is ablated. Eighty-seven mice were subjected to high voltage pulses directly delivered across parallel plate electrodes comprising around 40% of mouse liver. One group consisted in 55 athymicnude, in which a tumor from the KM12C cell line was grown and the other thirty-two C57-Bl6 nontumoral mice. Both groups were subsequently divided into subsets according to the delivered field strength (1000 V/cm, 2000 V/cm) and whether or not they received anti-hyperkalemia therapy. Early mortality (less than 24 hours post-IRE) in the 2000 V/cm group was observed and revealed considerably higher mean potassium levels. In contrast, the animals subjected to a 2000 V/cm field treated with the anti-hyperkalemia therapy had higher survival rates (OR = 0.1, 95%CI = 0.02-0.32, p < 0.001). Early mortality also depended on the electric field magnitude of the IRE protocol, as mice given 1000 V/cm survived longer than those given 2000 V/cm (OR = 4.7, 95% CI = 1.8-11.8, p = 0.001). Our findings suggest that ionic disturbances, mainly due to potassium alterations, should be warned and envisioned when large volume ablations are performed by IRE. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep23781 | - |
dc.relation.ispartof | Scientific Reports, 2016, vol. 6 | - |
dc.relation.uri | https://doi.org/10.1038/srep23781 | - |
dc.rights | cc by (c) Sánchez Velázquez et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Mortalitat | - |
dc.subject.classification | Malalties del fetge | - |
dc.subject.other | Mortality | - |
dc.subject.other | Liver diseases | - |
dc.title | Irreversible electroporation of the liver: is there a safe limit to the ablation volume? | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-25T07:51:01Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27032535 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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Sanchez-VelazquezP.pdf | 692.79 kB | Adobe PDF | View/Open |
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