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DC Field | Value | Language |
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dc.contributor.author | Heyn, Holger | - |
dc.date.accessioned | 2018-12-11T10:43:31Z | - |
dc.date.available | 2018-12-11T10:43:31Z | - |
dc.date.issued | 2016-03-03 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126874 | - |
dc.description.abstract | The interpretation of noncoding alterations in cancer genomes presents an unresolved problem in cancer studies. While the impact of somatic variations in protein-coding regions is widely accepted, noncoding aberrations are mostly considered as passenger events. However, with the advance of genome-wide profiling strategies, alterations outside the coding context entered the focus, and multiple examples highlight the role of gene deregulation as cancer-driving events. This review describes the implication of noncoding alterations in oncogenesis and provides a theoretical framework for the identification of causal somatic variants using quantitative trait loci (QTL) analysis. Assuming that functional noncoding alterations affect quantifiable regulatory processes, somatic QTL studies constitute a valuable strategy to pinpoint cancer gene deregulation. Eventually, the comprehensive identification and interpretation of coding and noncoding alterations will guide our future understanding of cancer biology. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pgen.1005826 | - |
dc.relation.ispartof | PLoS Genetics, 2016, vol. 12, num. 3, p. e1005826 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pgen.1005826 | - |
dc.rights | cc by (c) Heyn, Holger, 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Cancer | - |
dc.subject.other | Gene expression | - |
dc.title | Quantitative Trait Loci Identify Functional Noncoding Variation in Cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-25T07:51:55Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/282510 /EU//BLUEPRINT | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26938653 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
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