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DC Field | Value | Language |
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dc.contributor.author | Vera, Beatriz | - |
dc.contributor.author | Martínez Vélez, Naiara | - |
dc.contributor.author | Xipell, Enric | - |
dc.contributor.author | Acanda de la Rocha, Arlet | - |
dc.contributor.author | Patiño García, Ana | - |
dc.contributor.author | Saez Castresana, Javier | - |
dc.contributor.author | Gonzalez Huarriz, Marisol | - |
dc.contributor.author | Cascallò, Manel | - |
dc.contributor.author | Alemany Bonastre, Ramon | - |
dc.contributor.author | Alonso, Marta M. | - |
dc.date.accessioned | 2018-12-11T12:14:44Z | - |
dc.date.available | 2018-12-11T12:14:44Z | - |
dc.date.issued | 2016-01-25 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126898 | - |
dc.description.abstract | Despite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal. Therapy with tumor-selective viruses is emerging as a treatment option for this devastating disease. In this study we characterize the anti-glioma effect of VCN-01, an improved hyaluronidase-armed pRB-pathway-selective oncolytic adenovirus that has proven safe and effective in the treatment of several solid tumors. VCN-01 displayed a significant cytotoxic effect on glioma cells in vitro. In vivo, in two different orthotopic glioma models, a single intra-tumoral administration of VCN-01 increased overall survival significantly and led to long-term survivors free of disease. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0147211 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 1, p. e0147211 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0147211 | - |
dc.rights | cc by (c) Vera et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Glioma | - |
dc.subject.classification | Adenovirus | - |
dc.subject.other | Gliomas | - |
dc.subject.other | Adenoviruses | - |
dc.title | Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-25T07:53:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26808201 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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