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Title: | Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults |
Author: | Hoyo, Laura del Xicota, Laura Sánchez Benavides, Gonzalo Cuenca Royo, Aida Sola Llopis, Susana de Langohr, Klaus Fagundo, Ana Beatriz Farré Albaladejo, Magí Dierssen, Mara Torre Fornell, Rafael de la |
Keywords: | Síndrome de Down Malaltia d'Alzheimer Down syndrome |
Issue Date: | 18-Nov-2015 |
Publisher: | Frontiers Media |
Abstract: | Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal fluency are strongly impaired domains: nearly all adults show neuropathology of Alzheimer's disease (AD), including amyloid deposition by their fifth decade of life. In the general population, verbal fluency deficits are considered a strong AD predictor being the semantic verbal fluency task (SVFT) a useful tool for enhancing early diagnostic. However, there is a lack of information about the association between the semantic verbal fluency pattern (SVFP) and the biological amyloidosis markers in DS. In the current study, we used the SVFT in young adults with DS to characterize their SVFP, assessing total generated words, clustering, and switching. We then explored its association with early indicators of dementia, adaptive behavior and amyloidosis biomarkers, using the Dementia Questionnaire for Persons with Intellectual Disability (DMR), the Adaptive Behavior Assessment System-Second Edition (ABAS-II), and plasma levels of A beta peptides (A beta(40) and A beta(42)), as a potent biomarker of AD. In DS, worse performance in SVFT and poorer communication skills were associated with higher plasma A beta(42) concentrations, a higher DMR score and impaired communication skills (ABAS-II). The total word production and switching ability in SVFT were good indicators of plasma A beta(42) concentration. In conclusion, we propose the SVFT as a good screening test for early detection of dementia and amyloidosis in young adults with DS. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fnbeh.2015.00301 |
It is part of: | Frontiers in Behavioral Neuroscience, 2015, vol. 9 |
URI: | http://hdl.handle.net/2445/126932 |
Related resource: | https://doi.org/10.3389/fnbeh.2015.00301 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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