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Title: | Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: the role of gender (EMITRAL study) |
Author: | Torres, Armando Torregrosa Prats, José Vicente Marcen, Roberto Campistol Plana, Josep M. Arias, Manuel Hernández, Domingo Fernández, Constantino Esforzado Armengol, Nuria Paschoalin, Raphael Pérez, Nuria García, Ana Isabel Del Amo, Montserrat Pomés, Jaume González Rinne, Ana Marrero, Domingo Pérez, Estefanía Henríquez, Fernando Díaz, Juan Manuel Silva, Irene López, Verónica Perelló Carrascosa, Manuel Ramos, David Beneyto, Isabel Cruzado, Josep Ma. Martínez Castelao, Alberto Bravo, Juan Rodríguez, Minerva Díaz, Carmen Crespo, Josep Anaya, Fernando Rodríguez, María Luisa Cubero, Juan Jose Pascual, Pilar Romero, Rafael Andrés Belmonte, Amado Checa, María Dolores Jiménez, Carlos Escuin, Fernando Crespo, Marta Mir, Marisa Gómez, Gonzalo Bayes, Beatriz González, María José Gutiérrez Dalmau, Alex Cuberes, Marta Rodríguez Benoit, Alberto García, Teresa Llamas, Francisco Ortega, Agustín Conde, José Luis Gómez Alamillo, Carlos |
Keywords: | Trasplantament renal Vitamina D Gènere Metabolisme mineral Fractures Vèrtebres Calcificació Kidney transplantation Vitamin D Gender Mineral metabolism Fractures Vertebrae Calcification |
Issue Date: | May-2016 |
Publisher: | Elsevier España |
Abstract: | Background and objectives: The relationship between mineral metabolism disorders, bone fractures and vascular calcifications in kidney transplant recipients has not been established. Method: We performed a cross-sectional study in 727 stable recipients from 28 Spanish transplant clinics. Mineral metabolism parameters, the semi-quantification of vertebral fractures and abdominal aortic calcifications were determined centrally. Results: Vitamin D deficiency (250HD(3) <15 ng/ml) was more common in female recipients at CKD-T stages I-III (29.6% vs 44.4%; p = 0.003). The inverse and significant correlation between 250HD(3) and PTH was gender-specific and women exhibited a steeper slope than men (p = 0.01). Vertebral fractures (VFx) with deformity grade >= 2 were observed in 15% of recipients. Factors related to VFx differed by gender; in males, age (OR 1.04; 95% CI 1.01-1.06) and CsA treatment (OR: 3.2; 95% CI: 1.6-6.3); in females, age (OR 1.07; 95% CI: 1.03-1.12) and PTH levels (OR per 100 pg/ml increase: 1.27; 95% CI: 1.043-1.542). Abdominal aortic calcifications were common (67.2%) and related to classical risk factors but not to mineral metabolism parameters. Conclusions: Vitamin D deficiency is more common among female kidney transplant recipients at earlier CKD-T stages, and it contributes to secondary hyperparathyroidism. Prevalent vertebral fractures are only related to high serum PTH levels in female recipients. (C) 2016 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.nefro.2016.03.004 |
It is part of: | Nefrología, 2016, vol. 36, num. 3, p. 255-267 |
URI: | http://hdl.handle.net/2445/126943 |
Related resource: | https://doi.org/10.1016/j.nefro.2016.03.004 |
ISSN: | 0211-6995 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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