Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127086
Title: Treatment of patients with COPD and recurrent exacerbations: the role of infection and inflammation
Author: Santos Pérez, Salud
Marin, Alicia
Serra Batlles, Joan
Rosa, David de la
Solanes, Ingrid
Pomares, Xavier
López Sánchez, Marta
Muñoz Esquerre, Mariana
Miravitlles Fernández, Marc
Keywords: Malalties pulmonars obstructives cròniques
Inflamació
Infeccions
Chronic obstructive pulmonary diseases
Inflammation
Infections
Issue Date: 11-Mar-2016
Publisher: Dove Medical Press
Abstract: Exacerbations of COPD represent an important medical and health care problem. Certain susceptible patients suffer recurrent exacerbations and as a consequence have a poorer prognosis. The effects of bronchial infection, either acute or chronic, and of the inflammation characteristic of the disease itself raise the question of the possible role of antibiotics and anti-inflammatory agents in modulating the course of the disease. However, clinical guidelines base their recommendations on clinical trials that usually exclude more severe patients and patients with more comorbidities, and thus often fail to reflect the reality of clinicians attending more severe patients. In order to discuss aspects of clinical practice of relevance to pulmonologists in the treatment and prevention of recurrent exacerbations in patients with severe COPD, a panel discussion was organized involving expert pulmonologists who devote most of their professional activity to day hospital care. This article summarizes the scientific evidence currently available and the debate generated in relation to the following aspects: bacterial and viral infections, chronic bronchial infection and its treatment with cyclic oral or inhaled antibiotics, inflammatory mechanisms and their treatment, and the role of computerized tomography as a diagnostic tool in patients with severe COPD and frequent exacerbations.
Note: Reproducció del document publicat a: https://doi.org/10.2147/COPD.S98333
It is part of: International Journal of Chronic Obstructive Pulmonary Disease, 2016, vol. 11, p. 515-525
URI: https://hdl.handle.net/2445/127086
Related resource: https://doi.org/10.2147/COPD.S98333
ISSN: 1176-9106
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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