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http://hdl.handle.net/2445/127216
Title: | Allosterism and signal transfer in DNA |
Author: | Balaceanu, Alexandra Pérez, Alberto Dans, Pablo D. Orozco López, Modesto |
Keywords: | ADN Dinàmica molecular Proteïnes Lligands DNA Molecular dynamics Proteins Ligands |
Issue Date: | 14-Jun-2018 |
Publisher: | Oxford University Press |
Abstract: | We analysed the basic mechanisms of signal transmission in DNA and the origins of the allostery exhibited by systems such as the ternary complex BAMHI-DNA-GRDBD. We found that perturbation information generated by a primary protein binding event travels as a wave to distant regions of DNA following a hopping mechanism. However, such a structural perturbation is transient and does not lead to permanent changes in the DNA geometry and interaction properties at the secondary binding site. The BAMHI-DNA-GRDBD allosteric mechanism does not occur through any traditional models: direct (protein-protein), indirect (reorganization of the secondary site) readout or solvent-release. On the contrary, it is generated by a subtle and less common entropy-mediated mechanism, which might have an important role to explain other DNA-mediated cooperative effects. |
Note: | Reproducció del document publicat a: https://doi.org/10.1093/nar/gky549 |
It is part of: | Nucleic Acids Research, 2018, vol. 46, num. 15, p. 7554-7565 |
URI: | http://hdl.handle.net/2445/127216 |
Related resource: | https://doi.org/10.1093/nar/gky549 |
ISSN: | 0305-1048 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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