Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/127368
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DC Field | Value | Language |
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dc.contributor.author | Guinney, Justin | - |
dc.contributor.author | Dienstmann, Rodrigo | - |
dc.contributor.author | Wang, Xin | - |
dc.contributor.author | Reyniès, Aurélien de | - |
dc.contributor.author | Schlicker, Andreas | - |
dc.contributor.author | Soneson, Charlotte | - |
dc.contributor.author | Marisa, Laetitia | - |
dc.contributor.author | Roepman, Paul | - |
dc.contributor.author | Nyamundanda, Gift | - |
dc.contributor.author | Angelino, Paolo | - |
dc.contributor.author | Bot, Brian M. | - |
dc.contributor.author | Morris, Jeffrey | - |
dc.contributor.author | Simon, Iris M. | - |
dc.contributor.author | Gerster, Sarah | - |
dc.contributor.author | Fessler, Evelyn | - |
dc.contributor.author | Sousa e Melo, Felipe de | - |
dc.contributor.author | Missiaglia, Edoardo | - |
dc.contributor.author | Ramay, Hena | - |
dc.contributor.author | Barras, David | - |
dc.contributor.author | Homicsko, Krisztian | - |
dc.contributor.author | Maru, Dipen | - |
dc.contributor.author | Manyam, Ganiraju C. | - |
dc.contributor.author | Broom, Bradley | - |
dc.contributor.author | Boige, Valerie | - |
dc.contributor.author | Pérez Villamil, Beatriz | - |
dc.contributor.author | Laderas, Ted | - |
dc.contributor.author | Salazar Soler, Ramón | - |
dc.contributor.author | Gray, Joe W. | - |
dc.contributor.author | Hanahan, Douglas | - |
dc.contributor.author | Tabernero Caturla, Josep | - |
dc.contributor.author | Bernards, René | - |
dc.contributor.author | Friend, Stephen H. | - |
dc.contributor.author | Laurent Puig, Pierre | - |
dc.contributor.author | Medema, Jan Paul | - |
dc.contributor.author | Sadanandam, Anguraj | - |
dc.contributor.author | Wessels, Lodewyk F. A. | - |
dc.contributor.author | Delorenzi, Mauro | - |
dc.contributor.author | Kopetz, Scott | - |
dc.contributor.author | Vermeulen, Louis | - |
dc.contributor.author | Tejpar, Sabine | - |
dc.date.accessioned | 2019-01-17T09:33:17Z | - |
dc.date.available | 2019-01-17T09:33:17Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 1078-8956 | - |
dc.identifier.uri | http://hdl.handle.net/2445/127368 | - |
dc.description.abstract | Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international consortium dedicated to large-scale data sharing and analytics across expert groups. We show marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features: CMS1 (microsatellite instability immune, 14%), hypermutated, microsatellite unstable and strong immune activation; CMS2 (canonical, 37%), epithelial, marked WNT and MYC signaling activation; CMS3 (metabolic, 13%), epithelial and evident metabolic dysregulation; and CMS4 (mesenchymal, 23%), prominent transforming growth factor-beta activation, stromal invasion and angiogenesis. Samples with mixed features (13%) possibly represent a transition phenotype or intratumoral heterogeneity. We consider the CMS groups the most robust classification system currently available for CRC-with clear biological interpretability-and the basis for future clinical stratification and subtype-based targeted interventions. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/nm.3967 | - |
dc.relation.ispartof | Nature Medicine, 2015, vol. 21, num. 11, p. 1350-1356 | - |
dc.relation.uri | https://doi.org/10.1038/nm.3967 | - |
dc.rights | (c) Guinney, Justin et al., 2015 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Classificació de tumors | - |
dc.subject.classification | Oncologia | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Tumors classification | - |
dc.subject.other | Oncology | - |
dc.title | The consensus molecular subtypes of colorectal cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 664948 | - |
dc.date.updated | 2019-01-17T09:33:17Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/638193/EU//CRCStemCellDynamics | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26457759 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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664948.pdf | 1.91 MB | Adobe PDF | View/Open |
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