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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127382
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dc.contributor.authorAmat Tusón, Mercedes-
dc.contributor.authorFabregat, Robert-
dc.contributor.authorGriera Farres, Rosa-
dc.contributor.authorFlorindo, Pedro-
dc.contributor.authorMolins i Grau, Elies-
dc.contributor.authorBosch Cartes, Joan-
dc.date.accessioned2019-01-17T12:49:45Z-
dc.date.available2019-01-17T12:49:45Z-
dc.date.issued2010-03-31-
dc.identifier.issn0022-3263-
dc.identifier.urihttps://hdl.handle.net/2445/127382-
dc.description.abstractThe straightforward enantioselective construction of the hydroquinoline ring system from 1,5-polycarbonyl derivatives, using (R)-phenyglycinol as a chiral latent form of ammonia, is reported. The process mimics the key steps believed to occur in nature in the biosynthesis of amphibian decahydroquinoline alkaloids. Diastereodivergent routes to enantiopure cis-2,5-disubstituted decahydroquinolines, including the alkaloid pumiliotoxin C (cis-195A), are developed.-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1021/jo1005894-
dc.relation.ispartofJournal of Organic Chemistry, 2010, vol. 75, num. 11, p. 3797-3805-
dc.relation.urihttps://doi.org/10.1021/jo1005894-
dc.rights(c) American Chemical Society , 2010-
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)-
dc.subject.classificationBiosíntesi-
dc.subject.classificationBiomimètica-
dc.subject.classificationSíntesi asimètrica-
dc.subject.classificationSíntesi orgànica-
dc.subject.otherBiosynthesis-
dc.subject.otherBiomimetics-
dc.subject.otherAsymmetric synthesis-
dc.subject.otherOrganic synthesis-
dc.titleBiomimetic Construction of the Hydroquinoline Ring System. Diastereodivergent Enantioselective Synthesis of 2,5-Disubstituted cis-Decahydroquinolines-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec579354-
dc.date.updated2019-01-17T12:49:46Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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