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http://hdl.handle.net/2445/127424
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DC Field | Value | Language |
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dc.contributor.author | Díaz Beyà, Marina | - |
dc.contributor.author | Brunet, Salut | - |
dc.contributor.author | Nomdedéu Guinot, Josep Francesc | - |
dc.contributor.author | Cordeiro Santanach, Anna | - |
dc.contributor.author | Tormo, Mar | - |
dc.contributor.author | Escoda, Lourdes | - |
dc.contributor.author | Ribera, Josep Maria | - |
dc.contributor.author | Heras, Inmaculada | - |
dc.contributor.author | Gallardo Giralt, David | - |
dc.contributor.author | Bargay, Joan | - |
dc.contributor.author | Queipo de Llano, María Paz | - |
dc.contributor.author | Salamero, Olga | - |
dc.contributor.author | Martí, Josep María | - |
dc.contributor.author | Sampol, Antonia | - |
dc.contributor.author | Pedro, Carme | - |
dc.contributor.author | Hoyos Colell, Montserrat | - |
dc.contributor.author | Pratcorona, Marta | - |
dc.contributor.author | Castellano, Joan Josep | - |
dc.contributor.author | Nomdedeu i Fàbrega, Meritxell | - |
dc.contributor.author | Risueño, Ruth M. | - |
dc.contributor.author | Sierra Gil, Jorge | - |
dc.contributor.author | Monzó Planella, Mariano | - |
dc.contributor.author | Navarro Ponz, Alfons | - |
dc.contributor.author | Esteve Reyner, Jordi | - |
dc.contributor.author | Arnan, Montserrat | - |
dc.date.accessioned | 2019-01-18T11:41:29Z | - |
dc.date.available | 2019-01-18T11:41:29Z | - |
dc.date.issued | 2015-10-02 | - |
dc.identifier.issn | 2044-5385 | - |
dc.identifier.uri | http://hdl.handle.net/2445/127424 | - |
dc.description.abstract | Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (>= 60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P = 0.0025), shorter leukemia-free survival (P = 0.026) and higher cumulative incidence of relapse (P = 0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P = 0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/bcj.2015.76 | - |
dc.relation.ispartof | Blood Cancer Journal, 2015, vol. 5, p. e352 | - |
dc.relation.uri | https://doi.org/10.1038/bcj.2015.76 | - |
dc.rights | cc-by (c) Diaz Beya, Marina et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Leucèmia mieloide | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.classification | Malalts de càncer | - |
dc.subject.classification | Micro RNAs | - |
dc.subject.other | Myeloid leukemia | - |
dc.subject.other | Prognosis | - |
dc.subject.other | Cancer patients | - |
dc.subject.other | MicroRNAs | - |
dc.title | The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 654364 | - |
dc.date.updated | 2019-01-18T11:41:31Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26430723 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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654364.pdf | 1.44 MB | Adobe PDF | View/Open |
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