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http://hdl.handle.net/2445/127597
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DC Field | Value | Language |
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dc.contributor.author | Piccichè, Miriam | - |
dc.contributor.author | Pinto, Alexandre | - |
dc.contributor.author | Griera Farres, Rosa | - |
dc.contributor.author | Bosch Cartes, Joan | - |
dc.contributor.author | Amat Tusón, Mercedes | - |
dc.date.accessioned | 2019-01-25T09:11:41Z | - |
dc.date.available | 2019-01-25T09:11:41Z | - |
dc.date.issued | 2017-12-15 | - |
dc.identifier.issn | 1523-7060 | - |
dc.identifier.uri | http://hdl.handle.net/2445/127597 | - |
dc.description.abstract | A synthesis of (+)-gephyrotoxin 287C using, (S)-phenylglycinol-derived tricyclic lactam 7 as the starting enantiomeric scaffold is reported. From the stereochemical standpoint, the key steps are the generation of the DHQ C-5 stereocenter by hydrogenation of the C-C double bond, removal of the chiral inductor to give a cis-DHQ introduction of the DHQ C-2 substituent, completion of the (Z)-enyne moiety, and generation of the C-1 stereocenter during closure of the pyrrolidine ring. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/acs.orglett.7b03381 | - |
dc.relation.ispartof | Organic Letters, 2017, vol. 19, num. 24, p. 6654-6657 | - |
dc.relation.uri | https://doi.org/10.1021/acs.orglett.7b03381 | - |
dc.rights | (c) American Chemical Society , 2017 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Síntesi asimètrica | - |
dc.subject.classification | Lactames | - |
dc.subject.classification | Catàlisi asimètrica | - |
dc.subject.other | Asymmetric synthesis | - |
dc.subject.other | Lactams | - |
dc.subject.other | Enantioselective catalysis | - |
dc.title | Enantioselective Total Synthesis of (+)-Gephyrotoxin 287C | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 677696 | - |
dc.date.updated | 2019-01-25T09:11:41Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29182285 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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677696.pdf | 422.09 kB | Adobe PDF | View/Open |
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