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Title: Direct and asymmetric nickel(II)-catalyzed construction of carbon−carbon bonds from N‑acyl thiazinanethiones
Author: Kennington, Stuart C. D.
Taylor, Adam J.
Romea, Pedro
Urpí Tubella, Fèlix
Aullón López, Gabriel
Font Bardia, Ma. Mercedes
Ferré, Laura
Rodrigálvarez García, Jesús
Keywords: Catàlisi
Issue Date: 4-Jan-2019
Publisher: American Chemical Society
Abstract: A wide array of new N-acyl thiazinanethiones are employed in a number of direct and enantioselective carbon-carbon bond forming reactions catalyzed by nickel(II) complexes. The electrophilic species are mostly prepared in situ from ortho esters, methyl ethers, acetals, and ketals, which makes the overall process highly efficient and experimentally straightforward. Theoretical calculations indicate that the reactions pro-ceed through an open transition state in a SN1-like mechanism. The utility of this novel procedure has been demonstrated by the asymmetric preparation of syntheti-cally useful intermediates and the total synthesis of pe-peromin D.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2019, vol. 21, num. 1, p. 305-309
Related resource:
ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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