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http://hdl.handle.net/2445/127694
Title: | Direct and asymmetric nickel(II)-catalyzed construction of carbon−carbon bonds from N‑acyl thiazinanethiones |
Author: | Kennington, Stuart C. D. Taylor, Adam J. Romea, Pedro Urpí Tubella, Fèlix Aullón López, Gabriel Font Bardia, Ma. Mercedes Ferré, Laura Rodrigálvarez García, Jesús |
Keywords: | Catàlisi Níquel Catalysis Nickel |
Issue Date: | 4-Jan-2019 |
Publisher: | American Chemical Society |
Abstract: | A wide array of new N-acyl thiazinanethiones are employed in a number of direct and enantioselective carbon-carbon bond forming reactions catalyzed by nickel(II) complexes. The electrophilic species are mostly prepared in situ from ortho esters, methyl ethers, acetals, and ketals, which makes the overall process highly efficient and experimentally straightforward. Theoretical calculations indicate that the reactions pro-ceed through an open transition state in a SN1-like mechanism. The utility of this novel procedure has been demonstrated by the asymmetric preparation of syntheti-cally useful intermediates and the total synthesis of pe-peromin D. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acs.orglett.8b03757 |
It is part of: | Organic Letters, 2019, vol. 21, num. 1, p. 305-309 |
URI: | http://hdl.handle.net/2445/127694 |
Related resource: | https://doi.org/10.1021/acs.orglett.8b03757 |
ISSN: | 1523-7060 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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