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Title: | Neurotrophins role in depressive symptoms and executive function performance: Association analysis of NRN1 gene and its interaction with BDNF gene in a non-clinical sample. |
Author: | Prats Balado, Claudia Arias Sampériz, Bárbara Ortet i Fabregat, Generós Ibáñez Ribes, Manuel Ignacio Moya Higueras, Jorge Pomarol-Clotet, Edith Fañanás Saura, Lourdes Fatjó-Vilas Mestre, Mar |
Keywords: | Proteïnes Malalties mentals Neurones Proteins Mental illness Neurons |
Issue Date: | 15-Mar-2017 |
Publisher: | Elsevier B.V. |
Abstract: | BACKGROUND: Neuritin-1 is a neurotrophic factor involved in synaptic plasticity that has been associated with depressive disorders, schizophrenia and cognitive performance. The study of genotype-phenotype relationships in healthy individuals is a useful framework to investigate the etiology of brain dysfunctions. We therefore aimed to investigate in a non-clinical sample whether NRN1 gene contributes to the psychopathological profile, with a particular focus on the clinical dimensions previously related to the NRN1 gene (i.e. depressive and psychotic). Furthermore, we aimed to analyze: i) the role of NRN1 on executive functions, ii) whether the association between either NRN1-psychopathological profile or NRN1-cognitive performance is moderated by the BDNF gene. METHODS: The sample comprised 410 non-clinical subjects who filled in the self-reported Brief Symptom Inventory (BSI) and were assessed for executive performance (Verbal Fluency, Wisconsin Card Sorting Test (WCST) and Letter-Number subscale (WAIS-III)). Genotyping included nine SNPs in NRN1 and one in BDNF. RESULTS: i) GG homozygotes (rs1475157-NRN1) showed higher scores on BSI depressive dimension and on total scores compared to A carriers (corrected p-values: 0.0004 and 0.0003, respectively). ii) a linear trend was detected between GG genotype of rs1475157 and a worse cognitive performance in WCST total correct responses (uncorrected p-value: 0.029). iii) Interaction between rs1475157-NRN1 and Val66Met-BDNF was found to modulate depressive symptoms (p=0.001, significant after correction). LIMITATIONS: Moderate sample size; replication in a larger sample is needed. CONCLUSIONS: NRN1 is associated with depressive symptoms and executive function in a non-clinical sample. Our results also suggest that the role of NRN1 seems to be modulated by BDNF. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.jad.2016.11.017 |
It is part of: | Journal of Affective Disorders, 2017, vol. 211, p. 92-98 |
URI: | http://hdl.handle.net/2445/127787 |
Related resource: | https://doi.org/10.1016/j.jad.2016.11.017 |
ISSN: | 0165-0327 |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) |
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