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Title: A synthetic alternative to natural lecithins with antimicrobial properties
Author: Pérez, L.
Infante Martínez-Pardo, Ma. Rosa
Pons Pons, Ramon
Morán, C.
Vinardell Martínez-Hidalgo, Ma. Pilar
Mitjans Arnal, Montserrat
Pinazo Gassol, Aurora
Keywords: Síntesi orgànica
Interfícies biològiques
Agents antiinfecciosos
Agents tensioactius
Bioquímica analítica
Organic synthesis
Biological interfaces
Anti-infective agents
Surface active agents
Analytical biochemistry
Issue Date: 1-Jun-2004
Publisher: Elsevier B.V.
Abstract: Two soft biocompatible cationic surfactants from the amino acid arginine, 1,2-dilauroyl-3-acetylarginyl-rac-glycerol (1212RAc) and 1,2-dimirystoyl-3-acetylarginyl-rac-glycerol (1414RAc), were prepared. Their physicochemical properties show that they can be classified as multifunctional surfactants with self-aggregation behaviour comparable to that of short-chain lecithins. The two surfactants can simultaneously stabilise water-in-oil (W/O) droplets and oil-in-water (O/W) droplets, forming multiple emulsions. They have antimicrobial activity similar to that of conventional cationic surfactants and are as harmless as amphoteric betaines. These surfactants constitute an interesting alternative to the diglycerides and lecithins in formulations that require antimicrobial properties.
Note: Versió postprint del document publicat a:
It is part of: Colloids and Surfaces B-Biointerfaces, 2004, vol. 35, num. 3-4, p. 235-242
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ISSN: 0927-7765
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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