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Title: DNA gel particles: An overview
Author: Morán Badenas, María del Carmen
Vinardell Martínez-Hidalgo, Ma. Pilar
Infante Martínez-Pardo, Ma. Rosa
Miguel, M. Graça
Lindman, Björn, 1942-
Keywords: ADN
Agents tensioactius
Materials nanoestructurats
Sistemes d'alliberament de medicaments
Col·loides en medicina
Surface active agents
Nanostructured materials
Drug delivery systems
Colloids in medicine
Issue Date: Mar-2014
Publisher: Elsevier
Abstract: A general understanding of interactions between DNA and oppositely charged compounds forms the basis for developing novel DNA-based materials, including gel particles. The association strength, which is altered by varying the chemical structure of the cationic cosolute, determines the spatial homogeneity of the gelation process, creating DNA reservoir devices and DNA matrix devices that can be designed to release either single- (ssDNA) or double-stranded (dsDNA). This review covers recent developments on the topic of DNA gel particles formed in water-water emulsion-type interfaces. The degree of DNA entrapment, particle morphology, swelling/dissolution behaviour and DNA release responses are discussed as a function of the nature of the cationic agent used. On the basis of designing DNA gel particles for therapeutic purposes, recent studies on the determination of the surface hydrophobicity, the haemolytic and the cytotoxic assessments of the obtained DNA gel particles have been also reported.
Note: Versió postprint del document publicat a:
It is part of: Advances in Colloid and Interface Science, 2014, vol. 205, p. 240-256
Related resource:
ISSN: 0001-8686
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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