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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127915
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dc.contributor.authorBenabou Zdaou, Sanae-
dc.contributor.authorGaravís, Miguel-
dc.contributor.authorLyonnais, Sébastien-
dc.contributor.authorEritja i Casadellà, Ramon-
dc.contributor.authorGonzález, Carlos-
dc.contributor.authorGargallo Gómez, Raimundo-
dc.date.accessioned2019-02-05T13:25:32Z-
dc.date.available2019-02-05T13:25:32Z-
dc.date.issued2016-02-09-
dc.identifier.issn1463-9076-
dc.identifier.urihttps://hdl.handle.net/2445/127915-
dc.description.abstractThe nature and length of loops connecting cytosine tracts in i-motif structures may affect their stability. In this work, the influence of the nature of the nucleobases located in two of the loops of an intramolecular i-motif is studied using spectroscopy, separation techniques, and multivariate data analysis. Insertion of bases other than thymine induces an additional acid-base equilibrium with pKa~4.5. The presence of two guanine bases in the loops, placed opposite to each other, decreases the thermal stability of the structure. In contrast, thymine and cytosine bases in these positions stabilize the structure-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherRoyal Society of Chemistry-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1039/C5CP07428B-
dc.relation.ispartofPhysical Chemistry Chemical Physics, 2016, vol. 18, num. 11, p. 7997-8004-
dc.relation.urihttps://doi.org/10.1039/C5CP07428B-
dc.rights(c) Benabou Zdaou, Sanae et al., 2016-
dc.sourceArticles publicats en revistes (Enginyeria Química i Química Analítica)-
dc.subject.classificationADN-
dc.subject.classificationEspectroscòpia de ressonància magnètica nuclear-
dc.subject.classificationCromatografia de permeació per gel-
dc.subject.classificationElectroforesi-
dc.subject.otherDNA-
dc.subject.otherNuclear magnetic resonance spectroscopy-
dc.subject.otherGel permeation chromatography-
dc.subject.otherElectrophoresis-
dc.titleUnderstanding the effect of the nature of the nucleobase in the loops on the stability of the i-motif structure-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec656926-
dc.date.updated2019-02-05T13:25:32Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid26957024-
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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