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http://hdl.handle.net/2445/127963
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DC Field | Value | Language |
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dc.contributor.author | Sunyer, Raimon | - |
dc.contributor.author | Conte, Vito | - |
dc.contributor.author | Escribano, Jorge | - |
dc.contributor.author | Elosegui Artola, Alberto | - |
dc.contributor.author | Labernadie, Anna | - |
dc.contributor.author | Valon, Léo | - |
dc.contributor.author | Navajas Navarro, Daniel | - |
dc.contributor.author | García Aznar, José Manuel | - |
dc.contributor.author | Muñoz, José J. | - |
dc.contributor.author | Roca-Cusachs Soulere, Pere | - |
dc.contributor.author | Trepat Guixer, Xavier | - |
dc.date.accessioned | 2019-02-06T12:16:54Z | - |
dc.date.available | 2019-02-06T12:16:54Z | - |
dc.date.issued | 2016-09-09 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/2445/127963 | - |
dc.description.abstract | The ability of cells to follow gradients of extracellular matrix stiffness-durotaxis-has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent cells did not. This emergent mode of directed collective cell migration applied to a variety of epithelial cell types, required the action of myosin motors, and originated from supracellular transmission of contractile physical forces. To explain the observed phenomenology, we developed a generalized clutch model in which local stick-slip dynamics of cell-matrix adhesions was integrated to the tissue level through cell-cell junctions. Collective durotaxis is far more efficient than single-cell durotaxis; it thus emerges as a robust mechanism to direct cell migration during development, wound healing, and collective cancer cell invasion. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1126/science.aaf7119 | - |
dc.relation.ispartof | Science, 2016, vol. 353, num. 6304, p. 1157-1161 | - |
dc.relation.uri | https://doi.org/10.1126/science.aaf7119 | - |
dc.rights | (c) Sunyer, Raimon et al., 2016 | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Cèl·lules | - |
dc.subject.classification | Cèl·lules canceroses | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Cells | - |
dc.subject.other | Cancer cells | - |
dc.subject.other | Cancer | - |
dc.title | Collective cell durotaxis emerges from long-range intercellular force transmission | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 668391 | - |
dc.date.updated | 2019-02-06T12:16:54Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27609894 | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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668391.pdf | 1.45 MB | Adobe PDF | View/Open |
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