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Title: The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration
Author: Sánchez Botet, Abril
Gasa, Laura
Quandt, Eva
Hernández Ortega, Sara
Jiménez Fàbrega, Xavier
Mezquita, Pau
Carrasco García, Miquel Àngel
Kron, Stephen J.
Vidal-Bel, August
Villanueva Garatachea, Alberto
Ribeiro, Mariana P. C.
Clotet Erra, Josep
Keywords: Ciclines
Migració cel·lular
Càncer colorectal
Proliferació cel·lular
Cell migration
Colorectal cancer
Cell proliferation
Issue Date: 7-Aug-2018
Publisher: Nature Publishing Group
Abstract: Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8-10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role of the new subfamily of atypical cyclins remains elusive. Here we have performed a systematic analysis of the protein expression levels of eight atypical cyclins in human CRC tumours and several cell lines, and found that CNTD2 is significantly upregulated in CRC tissue compared to the adjacent normal one. CNTD2 overexpression in CRC cell lines increases their proliferation capacity and migration, as well as spheroid formation capacity and anchorage-independent growth. Moreover, CNTD2 increases tumour growth in vivo on xenograft models of CRC with wild-type BRAF. Accordingly, CNTD2 downregulation significantly diminished the proliferation of wild-type BRAF CRC cells, suggesting that CNTD2 may represent a new prognostic factor and a promising drug target in the management of CRC.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2018, vol. 8, p. 11797
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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