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http://hdl.handle.net/2445/128148
Title: | The Cytotoxicity of Epsilon toxin from Clostridium perfringens on lymphocytes is mediated by MAL protein expression |
Author: | Blanch Lozano, Marta Dorca Arévalo, Jonatan Not, Anna Cases, Mercè Gómez de Aranda Pulgarín, Inmaculada Martínez Yélamos, Antonio Martínez Yélamos, Sergio Solsona Sancho, Carles Blasi Cabús, Joan |
Keywords: | Clostridi Cèl·lules T Esclerosi múltiple Malalties autoimmunitàries Clostridium T cells Multiple sclerosis Autoimmune diseases |
Issue Date: | 1-Oct-2018 |
Publisher: | American Society for Microbiology |
Abstract: | Epsilon toxin (Etx) from Clostridium perfringens is a pore-forming protein that crosses the blood-brain barrier, binds to myelin, and, hence, has been suggested to be a putative agent for the onset of multiple sclerosis, a demyelinating neuroinflammatory disease. Recently, myelin and lymphocyte (MAL) protein has been identified to be a key protein in the cytotoxic effect of Etx; however, the association of Etx with the immune system remains a central question. Here, we show that Etx selectively recognizes and kills only human cell lines expressing MAL protein through a direct Etx-MAL protein interaction. Experiments on lymphocytic cell lines revealed that MAL protein-expressing T cells, but not B cells, are sensitive to Etx and reveal that the toxin may be used as a molecular tool to distinguish subpopulations of lymphocytes. The overall results open the door to investigation of the role of Etx and Clostridium perfringens on inflammatory and autoimmune diseases like multiple sclerosis. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1128/MCB.00086-18 |
It is part of: | Molecular and Cellular Biology, 2018, vol. 38, num. 19, p. 00086-18 |
URI: | http://hdl.handle.net/2445/128148 |
Related resource: | https://doi.org/10.1128/MCB.00086-18 |
ISSN: | 0270-7306 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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