Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/128323
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Santos, Victor S. | - |
dc.contributor.author | Goletti, Delia | - |
dc.contributor.author | Kontogianni, Konstantina | - |
dc.contributor.author | Adams, Emily R. | - |
dc.contributor.author | Molina Moya, Barbara | - |
dc.contributor.author | Domínguez Benítez, José | - |
dc.contributor.author | Crudu, Valeriu | - |
dc.contributor.author | Martins-Filho, Paulo R.S. | - |
dc.contributor.author | Ruhwald, Morten | - |
dc.contributor.author | Lawson, Lovett | - |
dc.contributor.author | Bimba, John S. | - |
dc.contributor.author | García-Basteiro, Alberto L. | - |
dc.contributor.author | Petrone, Linda | - |
dc.contributor.author | Kabeer, Basir S. | - |
dc.contributor.author | Reither, Klaus | - |
dc.contributor.author | Cuevas, Luis E. | - |
dc.date.accessioned | 2019-02-15T13:39:56Z | - |
dc.date.available | 2019-02-15T13:39:56Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 1198-743X | - |
dc.identifier.uri | http://hdl.handle.net/2445/128323 | - |
dc.description.abstract | Objectives: We examined the data reported in studies for diagnostic purposes and to discuss whether their intended use could be extended to triage, as rule-in or rule-out tests to select individuals who should undergo further confirmatory tests. Methods: We searched Scopus, PubMed and Web of Science with the terms ‘acute phase proteins,’ ‘IP-10,’ ‘tuberculosis,’ ‘screening’ and ‘diagnosis,’ extracted the sensitivity and specificity of the biomarkers and explored methodologic differences to explain performance variations. Summary estimates were calculated using random-effects models for overall pooled accuracy. The hierarchical summary receiver operating characteristic model was used for meta-analysis. Results: We identified 14, four and one studies for C-reactive protein (CRP), interferon γ–induced protein 10 (IP-10) and alpha-1-acid glycoprotein (AGP). The pooled CRP sensitivity/specificity (95% confidence interval) was 89% (80–96) and 57% (36–65). Sensitivity/specificity were higher in high-tuberculosis-burden countries (90%/64%), HIV-infected individuals (91%/61%) and community-based studies (90%/62%). IP-10 sensitivity/specificity in TB vs. non-TB studies was 85%/63% and in TB and HIV coinfected vs. other lung conditions 94%/21%. However, IP-10 studies included diverse populations and a high risk of bias, resulting in very low-quality evidence. AGP had 86%/93% sensitivity/specificity. Conclusions: Few studies have evaluated CRP, IP-10 and AGP for the triage of symptomatic patients. Their high sensitivity and moderate specificity warrant further prospective studies exploring whether their combined use could optimize performance. | - |
dc.format.extent | 32 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.cmi.2018.07.017 | - |
dc.relation.ispartof | Clinical Microbiology and Infection, 2019, vol. 25, num. 2, p. 169–177 | - |
dc.relation.uri | http://dx.doi.org/ 10.1016/j.cmi.2018.07.017 | - |
dc.rights | cc by-nc-nd (c) Santos et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Tuberculosi | - |
dc.subject.classification | Diagnòstic | - |
dc.subject.other | Tuberculosis | - |
dc.subject.other | Diagnosis | - |
dc.title | Acute phase proteins and IP-10 as triage tests for the diagnosis of tuberculosis: systematic review and meta-analysis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2019-02-14T15:17:58Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/643381/EU//TBVAC2020 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Santos_VS_Clin_Microbiol_Infect_2018.pdf | 1.24 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License