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DC Field | Value | Language |
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dc.contributor.author | Requena-Méndez, Ana | - |
dc.contributor.author | Davies, Geraint | - |
dc.contributor.author | Waterhouse, David | - |
dc.contributor.author | Ardrey, Alison | - |
dc.contributor.author | Jave, Oswaldo | - |
dc.contributor.author | Llanet López-Romero, Sonia | - |
dc.contributor.author | Ward, Stephen A. | - |
dc.contributor.author | Moore, David A. J. | - |
dc.date.accessioned | 2019-02-15T14:14:03Z | - |
dc.date.available | 2019-11-08T06:10:17Z | - |
dc.date.issued | 2018-11-08 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.uri | http://hdl.handle.net/2445/128328 | - |
dc.description.abstract | Background: Poor response to TB therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic parameters can be affected by comorbidities or the interaction of drugs with food. Objectives: This study aimed to determine the effect of food intake upon pharmacokinetics of rifampicin and isoniazid in a Peruvian population with TB. Methods: Rifampicin and isoniazid levels were analysed at 2, 4 and 6 h after drug intake in both fasting and non-fasting states using LC-MS methods. Results: Sixty patients participated in the study. The median rifampicin Cmax and AUC0–6 were higher during fasting than non-fasting: 7.02 versus 6.59 mg/L (P = 0.054) and 28.64 versus 24.31 mg·h/L (P = 0.002). There was a statistically significant delay overall of non-fasting Tmax compared with the fasting state Tmax (P = 0.005). In the multivariate analysis, besides the effect of fasting, Cmax for females was 20% higher than for males (P = 0.03). Concerning isoniazid, there were significant differences in the Cmax during non-fasting (median = 3.51 mg/L) compared with fasting (4.54 mg/L). The isoniazid dose received had an effect upon the isoniazid levels (1.26, P = 0.038). In the multivariate analysis, isoniazid exposure during fasting was found to be 14% higher than during non-fasting (CI = 1.02–1.28, P < 0.001). Neither radiological extent of the disease nor consumption of food with drug intake nor pharmacokinetics of rifampicin or isoniazid was associated with a poorer treatment outcome. Conclusions: Rifampicin in particular and isoniazid pharmacokinetics were significantly affected by the intake of the drug with food between and within individuals. | ca |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Oxford University Press | ca |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/ 10.1093/jac/dky444 | - |
dc.relation.ispartof | Journal of Antimicrobial Chemotherapy, 2019, vol. 74, num. 2, p. 416–424 | - |
dc.relation.uri | http://dx.doi.org/ 10.1093/jac/dky444 | - |
dc.rights | (c) Oxford University Press, 2019 | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Tuberculosi | - |
dc.subject.classification | Farmacocinètica | - |
dc.subject.other | Tuberculosis | - |
dc.subject.other | Pharmacokinetics | - |
dc.title | Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.date.updated | 2019-02-14T15:18:18Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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Requena-Mendez_A_J_Antimicrob_Chemother_2018.pdf | 235.86 kB | Adobe PDF | View/Open |
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