Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/128361
Title: | Hydrogen Atom Transfer (HAT)-Triggered Iron-Catalyzed Intra- and Intermolecular Coupling of Alkenes with Hydrazones: Access to Complex Amines |
Author: | Saladrigas, Mar Loren, Guillem Bonjoch i Sesé, Josep Bradshaw, Ben |
Keywords: | Amines Alquens Catàlisi Enllaços químics Química orgànica Amines Alkenes Catalysis Chemical bonds Organic chemistry |
Issue Date: | Nov-2018 |
Publisher: | American Chemical Society |
Abstract: | A methodology for the coupling of alkenes with aldehyde- or ketone-derived Cbz-hydrazones to form a new C−C bond through a radical process is described. The sequence comprises an initial in situ generation of a putative iron hydride followed by a hydrogen atom transfer to an alkene, a coupling with a hydrazone, and a final reduction of the nitrogen-centered radical. Hydrogenation of the obtained hydrazines renders amines, including valuable tert-alkyl amines. KEYWORDS: HAT, iron catalysis, α-tert-amines, C−C bond formation, radical processes, synthetic methods |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acscatal.8b03794 |
It is part of: | ACS Catalysis, 2018, vol. 8, p. 11699-11703 |
URI: | http://hdl.handle.net/2445/128361 |
Related resource: | https://doi.org/10.1021/acscatal.8b03794 |
ISSN: | 2155-5435 |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
683227.pdf | 385.52 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.