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Title: Collective dynamics of interacting molecular motors
Author: Campàs, O.
Kafri, Y.
Zeldovich, K.
Casademunt i Viader, Jaume
Joanny, J. F.
Keywords: Dinàmica molecular
Molecular dynamics
Issue Date: 2006
Publisher: American Physical Society
Abstract: The collective dynamics of N interacting processive molecular motors are considered theoretically when an external force is applied to the leading motor. We show, using a discrete lattice model, that the force-velocity curves strongly depend on the effective dynamic interactions between motors and differ significantly from those of a simple approach where the motors equally share the force. Moreover, they become essentially independent of the number of motors if N is large enough (N * 5 for conventional kinesin). We show that a two-state ratchet model has a very similar behavior to that of the coarse-grained lattice model with effective interactions. The general picture is unaffected by motor attachment and detachment events.
Note: Reproducció digital del document proporcionada per PROLA i
It is part of: Physical Review Letters, 2006, vol. 97, núm. 3, p. 038101-1-038101-4
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ISSN: 0031-9007
Appears in Collections:Articles publicats en revistes (Física Quàntica i Astrofísica)

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