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|Collective dynamics of interacting molecular motors
Casademunt i Viader, Jaume
Joanny, J. F.
|American Physical Society
|The collective dynamics of N interacting processive molecular motors are considered theoretically when an external force is applied to the leading motor. We show, using a discrete lattice model, that the force-velocity curves strongly depend on the effective dynamic interactions between motors and differ significantly from those of a simple approach where the motors equally share the force. Moreover, they become essentially independent of the number of motors if N is large enough (N * 5 for conventional kinesin). We show that a two-state ratchet model has a very similar behavior to that of the coarse-grained lattice model with effective interactions. The general picture is unaffected by motor attachment and detachment events.
|Reproducció digital del document proporcionada per PROLA i http://dx.doi.org/10.1103/PhysRevLett.97.038101
|It is part of:
|Physical Review Letters, 2006, vol. 97, núm. 3, p. 038101-1-038101-4
|Appears in Collections:
|Articles publicats en revistes (Física Quàntica i Astrofísica)
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