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http://hdl.handle.net/2445/128524
Title: | A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to cutaneous and uveal melanoma patients |
Author: | García Martin, Margarita Moreno Olié, Rafael Gil-Martín, Marta Cascallò, Manel Ochoa de Olza, Maria Cuadra, Carmen Piulats, Josep M. Navarro-Pérez, Valentin Domenech, Marta Alemany Bonastre, Ramon Salazar Soler, Ramón |
Keywords: | Melanoma Virus oncogènics Herpes Oncogenic viruses Herpesvirus diseases |
Issue Date: | 18-Sep-2018 |
Publisher: | Mary Ann Liebert, Inc. |
Abstract: | Oncolytic viruses represent a unique type of agents that combine self-amplification, lytic, and immunostimulatory properties against tumors. A local and locoregional clinical benefit has been demonstrated upon intratumoral injections of an oncolytic herpes virus in melanoma patients, leading to its approval in the United States and Europe for patients without visceral disease (up to stage IVM1a). However, in order to debulk and change the local immunosuppressive environment of tumors that cannot be injected directly, oncolyitc viruses need to be administered systemically. Among different viruses, adenovirus has been extensively used in clinical trials but with few evidences of activity upon systemic administration. Preclinical efficacy of a single intravenous administration of our oncolytic adenovirus ICOVIR5, an adenovirus type 5 responsive to the retinoblastoma pathway commonly deregulated in tumors, led us to use this virus in a dose-escalation phase 1 trial in metastatic melanoma patients. The results in 12 patients treated with a single infusion of a dose up to 1 × 1013 viral particles show that ICOVIR5 can reach melanoma metastases upon a single intravenous administration but fails to induce tumor regressions. These results support the systemic administration of armed oncolytic viruses to treat disseminated cancer. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1089/hum.2018.107 |
URI: | http://hdl.handle.net/2445/128524 |
Related resource: | http://dx.doi.org/10.1089/hum.2018.107 |
ISSN: | 1557-7422 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Garcia et al. ICOVIR5 trial.pdf | 2.41 MB | Adobe PDF | View/Open |
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