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http://hdl.handle.net/2445/128531
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DC Field | Value | Language |
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dc.contributor.author | Garcia Vidal, Carolina | - |
dc.contributor.author | Cardozo Espinola, Celia | - |
dc.contributor.author | Puerta Alcalde, Pedro | - |
dc.contributor.author | Marco Reverté, Francesc | - |
dc.contributor.author | Tellez, Adrian | - |
dc.contributor.author | Agüero, Daiana | - |
dc.contributor.author | Romero Santana, Francisco | - |
dc.contributor.author | Díaz Beyà, Marina | - |
dc.contributor.author | Giné Soca, Eva | - |
dc.contributor.author | Morata, Laura | - |
dc.contributor.author | Rodríguez Núñez, Olga | - |
dc.contributor.author | Martínez, José Antonio | - |
dc.contributor.author | Mensa Pueyo, Josep | - |
dc.contributor.author | Esteve, Jordi | - |
dc.contributor.author | Soriano Viladomiu, Alex | - |
dc.date.accessioned | 2019-02-20T15:29:20Z | - |
dc.date.available | 2019-02-20T15:29:20Z | - |
dc.date.issued | 2018-06-28 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/128531 | - |
dc.description.abstract | Objectives: We assess the epidemiology and risk factors for mortality of bloodstream infection (BSI) in patients with acute leukemia (AL). Methods: Prospectively collected data of a cohort study from July 2004 to February 2016. Multivariate analyses were performed. Results: 589 episodes of BSI were documented in 357 AL patients, 55% caused by gram-positive bacteria (coagulase-negative staphylococci 35.7%, Enterococcus spp 10.8%) and 43.5% by gram-negative bacteria (E. coli 21%, PA 12%). We identified 110 (18.7%) multidrug-resistant (MDR) microorganisms, especially MDR-Pseudomonas aeruginosa (7%) and extended-spectrum beta-lactamase producing Enterobacteriaceae (7%). The 30-day mortality was 14.8%. Age (OR 3.1; 95% CI 1.7–5.7); chronic lung disease (4.8; 1.1–21.8); fatal prognosis according to McCabe index (13.9; 6.4–30.3); shock (3.8; 1.9–7.7); pulmonary infection (3.6; 1.3–9.9); and MDR-PA infections with inappropriate treatment (12.8; 4.1–40.5) were related to mortality. MDR-PA BSI was associated to prior antipseudomonal cephalosporin use (9.31; 4.38–19.79); current use of betalactams (2.01; 1.01–4.3); shock (2.63; 1.03–6.7) and pulmonary source of infection (9.6; 3.4–27.21). Conclusions: MDR organisms were commonly isolated in BSI in AL. Inappropriate empiric antibiotic treatment for MDR-PA is the primary factor related to mortality that can be changed. New treatment strategies to improve the coverage of MDR-PA BSI should be considered in those patients with risk factors for this infection. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0199531 | - |
dc.relation.ispartof | PLoS One, 2018, vol. 13, num. 6, p. e0199531 | - |
dc.relation.uri | http://dx.doi.org/ 10.1371/journal.pone.0199531 | - |
dc.rights | cc by (c) Garcia Vidal, 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Leucèmia | - |
dc.subject.classification | Mortalitat | - |
dc.subject.other | Leukemia | - |
dc.subject.other | Mortality | - |
dc.title | Risk factors for mortality in patients with acute leukemia and bloodstream infections in the era of multiresistance | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2019-02-14T15:59:51Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29953464 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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journal.pone.0199531_MMarcos.pdf | 605.13 kB | Adobe PDF | View/Open |
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