Please use this identifier to cite or link to this item:
Title: Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study
Author: Cano Català, Marta
Martínez Zalacaín, Ignacio
Bernabeu-Sanz, Ana Ávila
Contreras Rodríguez, Oren
Hernández Ribas, Rosa
Via Virgili, Esther
De Arriba Arnau, Aida
Galvez, Veronica
Urretavizcaya Sarachaga, Mikel
Pujol Nuez, Jesús
Menchón Magriñá, José Manuel
Cardoner, N. (Narcís)
Soriano Mas, Carles
Keywords: Diagnòstic per la imatge
Depressió psíquica
Resistència als medicaments
Diagnostic imaging
Mental depression
Drug resistance
Electric shock
Issue Date: 7-Feb-2017
Publisher: Nature Publishing Group
Abstract: Recent research suggests that neuroplastic and neuroinflammatory changes may account for the mode of action of electroconvulsive therapy (ECT), although extant data do not allow for a clear disambiguation between these two hypotheses. Multimodal neuroimaging approaches (for example, combining structural and metabolic information) may help in clarifying this issue. Here we aimed to assess longitudinal changes in (i) regional gray matter (GM) volumes and (ii) hippocampal metabolite concentrations throughout an acute course of bitemporal ECT, as well as (iii) to determine the association between imaging changes and clinical improvement. We assessed 12 patients with treatment-resistant depression (TRD) at four time points (pretreatment, after the first ECT session, after the ninth ECT session and 15 days after ECT course completion) and 10 healthy participants at two time points, 5 weeks apart. Patients with TRD showed bilateral medial temporal lobe (MTL) and perigenual anterior cingulate cortex volume increases. Left MTL volume increase was associated with (i) a hippocampal N-acetylaspartate concentration decrease, (ii) a hippocampal Glutamate+ Glutamine concentration increase and (iii) significant clinical improvement. The observed findings are, in part, compatible with both neuroplastic and neuroinflammatory changes induced by ECT. We postulate that such phenomena may be interrelated, therefore reconciling the neuroplasticity and neuroinflammatory hypotheses of ECT action.
Note: Reproducció del document publicat a:
It is part of: Translational Psychiatry, 2017, vol. 7, num. 2, p. e1023
Related resource:
ISSN: 2158-3188
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

Files in This Item:
File Description SizeFormat 
676886.pdf844.69 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons