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http://hdl.handle.net/2445/128818
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DC Field | Value | Language |
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dc.contributor.author | Barrett, Jennifer H. | - |
dc.contributor.author | Iles, Mark M. | - |
dc.contributor.author | Harland, Mark | - |
dc.contributor.author | Taylor, John C. | - |
dc.contributor.author | Aitken, Joanne F. | - |
dc.contributor.author | Andresen, Per Arne | - |
dc.contributor.author | Akslen, Lars A. | - |
dc.contributor.author | Armstrong, Bruce K. | - |
dc.contributor.author | Avril, Marie F. | - |
dc.contributor.author | Azizi, Esther | - |
dc.contributor.author | Bakker, Bert | - |
dc.contributor.author | Bergman, Wilma | - |
dc.contributor.author | Bianchi Scarrà, Giovanna | - |
dc.contributor.author | Bressac-de Paillerets, Brigitte | - |
dc.contributor.author | Calista, Donato | - |
dc.contributor.author | Cannon-Albright, Lisa A. | - |
dc.contributor.author | Corda, Eve | - |
dc.contributor.author | Cust, Anne E. | - |
dc.contributor.author | Dębniak, Tadeusz | - |
dc.contributor.author | Duffy, David | - |
dc.contributor.author | Dunning, Alison M. | - |
dc.contributor.author | Easton, Douglas F. | - |
dc.contributor.author | Friedman, Eitan | - |
dc.contributor.author | Galan, Pilar | - |
dc.contributor.author | Ghiorzo, Paola | - |
dc.contributor.author | Giles, Graham G. | - |
dc.contributor.author | Hansson, Johan | - |
dc.contributor.author | Hocevar, Marko | - |
dc.contributor.author | Höiom, Veronica | - |
dc.contributor.author | Hopper, John L. | - |
dc.contributor.author | Ingvar, Christian | - |
dc.contributor.author | Janssen, Bart | - |
dc.contributor.author | Jenkins, Mark A. | - |
dc.contributor.author | Jönsson, Göran | - |
dc.contributor.author | Kefford, Richard F. | - |
dc.contributor.author | Landi, Giorgio | - |
dc.contributor.author | Landi, Maria Teresa | - |
dc.contributor.author | Lang, Julie | - |
dc.contributor.author | Lubinski, Jan | - |
dc.contributor.author | Mackie, Rona | - |
dc.contributor.author | Malvehy, J. (Josep) | - |
dc.contributor.author | Martin, Nicholas G. | - |
dc.contributor.author | Molven, Anders | - |
dc.contributor.author | Montgomery, Grant W. | - |
dc.contributor.author | Nieuwpoort, Frans A. van | - |
dc.contributor.author | Novakovic, Srdjan | - |
dc.contributor.author | Olsson, Håkan | - |
dc.contributor.author | Pastorino, Lorenza | - |
dc.contributor.author | Puig i Sardà, Susana | - |
dc.contributor.author | Puig Butillé, Joan Anton | - |
dc.contributor.author | Randerson-Moor, Juliette | - |
dc.contributor.author | Snowden, Helen | - |
dc.contributor.author | Tuominen, Raider | - |
dc.contributor.author | Belle, Patricia van | - |
dc.contributor.author | Stoep, Nienke van der | - |
dc.contributor.author | Whiteman, David C. | - |
dc.contributor.author | Zelenika, Diana | - |
dc.contributor.author | Han, Jiali | - |
dc.contributor.author | Fang, Shenying | - |
dc.contributor.author | Lee, Jeffrey E. | - |
dc.contributor.author | Wei, Qingyi | - |
dc.contributor.author | Lathrop, Mark | - |
dc.contributor.author | Gillanders, Elizabeth M. | - |
dc.contributor.author | Brown, Kevin M. | - |
dc.contributor.author | Goldstein, Alisa M. | - |
dc.contributor.author | Kanetsky, Peter A. | - |
dc.contributor.author | Mann, Graham J. | - |
dc.contributor.author | MacGregor, Stuart | - |
dc.contributor.author | Elder, David E. | - |
dc.contributor.author | Amos, Christopher I. | - |
dc.contributor.author | Hayward, Nicholas K. | - |
dc.contributor.author | Gruis, Nelleke A. | - |
dc.contributor.author | Demenais, Florence | - |
dc.contributor.author | Newton-Bishop, Julia A. | - |
dc.contributor.author | Bishop, D. Timothy | - |
dc.contributor.author | GenoMEL Consortium | - |
dc.date.accessioned | 2019-02-25T16:04:31Z | - |
dc.date.available | 2019-02-25T16:04:31Z | - |
dc.date.issued | 2011-10-09 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | http://hdl.handle.net/2445/128818 | - |
dc.description.abstract | We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10−5 and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10−3: an SNP in ATM (rs1801516, overall P = 3.4 × 10−9), an SNP in MX2 (rs45430, P = 2.9 × 10−9) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 × 10−10). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 × 10−7 under a fixed-effects model and P = 1.2 × 10−3 under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/ng.959 | - |
dc.relation.ispartof | Nature Genetics, 2011, vol. 43, num. 11, p. 1008-1113 | - |
dc.relation.uri | https://doi.org/10.1038/ng.959 | - |
dc.rights | (c) Barrett, Jennifer H. et al., 2011 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Melanoma | - |
dc.subject.classification | Genètica mèdica | - |
dc.subject.classification | Càncer de pell | - |
dc.subject.other | Melanoma | - |
dc.subject.other | Medical genetics | - |
dc.subject.other | Skin cancer | - |
dc.title | Genome-wide association study identifies three new melanoma susceptibility loci | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 636619 | - |
dc.date.updated | 2019-02-25T16:04:31Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 21983787 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
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636619.pdf | 424.66 kB | Adobe PDF | View/Open |
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