Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/129163
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DC Field | Value | Language |
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dc.contributor.author | Armangué, Thaís | - |
dc.contributor.author | Leypoldt, Frank | - |
dc.contributor.author | Málaga, Ignacio | - |
dc.contributor.author | Raspall Chaure, Miquel | - |
dc.contributor.author | Marti, Itxaso | - |
dc.contributor.author | Nichter, Charles | - |
dc.contributor.author | Pugh, John | - |
dc.contributor.author | Vicente-Rasoamalala, Mónica | - |
dc.contributor.author | Lafuente-Hidalgo, Miguel | - |
dc.contributor.author | Macaya Ruiz, Alfons | - |
dc.contributor.author | Ke, Michael | - |
dc.contributor.author | Titulaer, Maarten J. | - |
dc.contributor.author | Höftberger, Romana | - |
dc.contributor.author | Sheriff, Heather | - |
dc.contributor.author | Glaser, Carol | - |
dc.contributor.author | Dalmau Obrador, Josep | - |
dc.date.accessioned | 2019-02-27T16:14:44Z | - |
dc.date.available | 2019-02-27T16:14:44Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | http://hdl.handle.net/2445/129163 | - |
dc.description.abstract | In 5 prospectively diagnosed patients with relapsing post-herpes simplex encephalitis (HSE), N-methyl-D-aspartate receptor (NMDAR) antibodies were identified. Antibody synthesis started 1 to 4 weeks after HSE, preceding the neurological relapse. Three of 5 patients improved postimmunotherapy, 1 spontaneously, and 1 has started to improve. Two additional patients with NMDAR antibodies, 9 with unknown neuronal surface antibodies, and 1 with NMDAR and unknown antibodies, were identified during retrospective assessment of 34 HSE patients; the frequency of autoantibodies increased over time (serum, p=0.004; cerebrospinal fluid, p=0.04). The 3 retrospectively identified NMDAR antibody-positive patients also had evidence of relapsing post-HSE. Overall, these findings indicate that HSE triggers NMDAR antibodies and potentially other brain autoimmunity. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/ana.24083 | - |
dc.relation.ispartof | Annals of Neurology, 2013, vol. 75, num. 2, p. 317-323 | - |
dc.relation.uri | https://doi.org/10.1002/ana.24083 | - |
dc.rights | (c) American Neurological Association, 2013 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Encefalitis | - |
dc.subject.classification | Herpes | - |
dc.subject.classification | Autoimmunitat | - |
dc.subject.classification | Malalties cerebrals | - |
dc.subject.other | Encephalitis | - |
dc.subject.other | Herpesvirus diseases | - |
dc.subject.other | Autoimmunity | - |
dc.subject.other | Brain diseases | - |
dc.title | Herpes simplex virus encephalitis is a trigger of brain autoimmunity | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 654343 | - |
dc.date.updated | 2019-02-27T16:14:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24318406 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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654343.pdf | 1.17 MB | Adobe PDF | View/Open |
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