Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/129426
Title: | Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project |
Author: | Martin Trias, Pablo Lanteaume, Laura Solana, Elisabeth Cassé Perrot, Catherine Fernández Cabello, Sara Babiloni, Claudio Marzano, Nicola Junqué i Plaja, Carme, 1955- Rossini, Paolo Maria Micallef, Joëlle Truillet, Romain Charles, Estelle Jouve, Elisabeth Bordet, Régis Santamaria Cano, Joan Jovicich, Jorge Rossi, Simone Pascual Leone, Álvaro, 1961- Blin, Olivier Richardson, Jill Bartrés Faz, David |
Keywords: | Escorça cerebral Neurociència cognitiva Estimulació del cervell Cerebral cortex Cognitive neuroscience Brain stimulation |
Issue Date: | 19-Jun-2018 |
Publisher: | Nature Publishing Group |
Abstract: | Transcranial magnetic stimulation (TMS) can interfere with cognitive processes, such as transiently impairing memory. As part of a multi-center European project, we investigated the adaptability and reproducibility of a previously published TMS memory interfering protocol in two centers using EEG or fMRI scenarios. Participants were invited to attend three experimental sessions on different days, with sham repetitive TMS (rTMS) applied on day 1 and real rTMS on days 2 and 3. Sixty-eight healthy young men were included. On each experimental day, volunteers were instructed to remember visual pictures while receiving neuronavigated rTMS trains (20 Hz, 900 ms) during picture encoding at the left dorsolateral prefrontal cortex (L-DLPFC) and the vertex. Mixed ANOVA model analyses were performed. rTMS to the L-DLPFC significantly disrupted recognition memory on experimental day 2. No differences were found between centers or between fMRI and EEG recordings. Subjects with lower baseline memory performances were more susceptible to TMS disruption. No stability of TMS-induced memory interference could be demonstrated on day 3. Our data suggests that adapted cognitive rTMS protocols can be implemented in multi-center studies incorporating standardized experimental procedures. However, our center and modality effects analyses lacked sufficient statistical power, hence highlighting the need to conduct further studies with larger samples. In addition, inter and intra-subject variability in response to TMS might limit its application in crossover or longitudinal studies. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-27502-1. |
It is part of: | Scientific Reports, 2018, vol. 8, num. 9371 |
URI: | https://hdl.handle.net/2445/129426 |
Related resource: | https://doi.org/10.1038/s41598-018-27502-1. |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
682839.pdf | 1.73 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License