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Title: Extending the substrate scope in the hydrogenation of unfunctionalized tetrasubstituted olefins with Ir-P stereogenic aminophosphine-oxazoline catalysts
Author: Biosca, Maria
Salomó i Prat, Ernest
Cruz Sánchez, Pol de la
Riera i Escalé, Antoni
Verdaguer i Espaulella, Xavier
Pàmies, Oscar
Diéguez, Montserrat
Keywords: Hidrogenació
Lligands (Bioquímica)
Ligands (Biochemistry)
Issue Date: 16-Jan-2019
Publisher: American Chemical Society
Abstract: Air stable and readily available Ir-catalyst precursors modified with MaxPHOX-type ligands have been successfully applied in the challenging asymmetric hydrogenation of tetrasubstituted olefins under mild reaction conditions. Gratifyingly, these catalyst precursors are not only able to efficiently hydrogenate a range of indene derivatives (ee's up to 96%) but also 1,2-dihydro-napthalene derivatives and acyclic olefins (ee's up to 99%), which both constitute the most challenging substrates for this transformation.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2019, vol. 21, num. 3, p. 807-811
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ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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