Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/129964| Title: | The Role of SeDeM Characterizing the Active Substance and Polyvynilpyrrolidone Eliminating Metastable Forms in an Oral Lyophilizate - A Preformulation Study. |
| Author: | Flórez Borges, Paloma Pérez Lozano, Pilar García Montoya, Encarna Miñarro Carmona, Montserrat Jo, Enric Manich Bou, Albert Suñé i Negre, Josep M. (Josep Maria) |
| Keywords: | Administració de medicaments Medicació oral Medicaments Disseny de medicaments Administration of drugs Oral medication Drugs Drug design |
| Issue Date: | 24-Apr-2018 |
| Publisher: | Public Library of Science (PLoS) |
| Abstract: | A preformulation study of an oral lyophilisate with cetirizine dihydrochloride (CTZ) as active ingredient, mannitol and PVP K30 as bulking agents is presented. CTZ shown a humidity content of 0.150% and a spontaneous hygroscopicity of 0.200% (both determined by SeDeM diagram), demonstrating an adequate stability behavior in solid form. A design of experiments (DoE) performed with both mannitol and PVP K30, followed by a simple factorial design (32) has determined the optimum combination of excipients and CTZ, and showed that a higher proportion of PVP K30 was able to prevent metastable forms generated by mannitol. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0196049 |
| It is part of: | PLoS One, 2018, vol. 13, num. 4, p. e0196049 |
| URI: | http://hdl.handle.net/2445/129964 |
| Related resource: | https://doi.org/10.1371/journal.pone.0196049 |
| ISSN: | 1932-6203 |
| Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 681312.pdf | 1.11 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License
