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http://hdl.handle.net/2445/130119
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DC Field | Value | Language |
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dc.contributor.author | Gómez Miragaya, Jorge | - |
dc.contributor.author | Palafox Sánchez, Marta | - |
dc.contributor.author | Paré, Laia | - |
dc.contributor.author | Yoldi, Guillermo | - |
dc.contributor.author | Ferrer, Irene | - |
dc.contributor.author | Vila, Sergi | - |
dc.contributor.author | Galván, Patricia | - |
dc.contributor.author | Pellegrini, Pasquale | - |
dc.contributor.author | Pérez-Montoyo, Hector | - |
dc.contributor.author | Igea, Ana | - |
dc.contributor.author | Muñoz Moruno, Purificación | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Nebreda, Àngel R. | - |
dc.contributor.author | Urruticoechea Ribate, Ander | - |
dc.contributor.author | Morilla, Idoia | - |
dc.contributor.author | Pernas, Sònia | - |
dc.contributor.author | Climent, Fina | - |
dc.contributor.author | Soler, María Teresa | - |
dc.contributor.author | Petit, Anna | - |
dc.contributor.author | Serra Elizalde, Violeta | - |
dc.contributor.author | Prat Aparicio, Aleix | - |
dc.contributor.author | González Suárez, Eva | - |
dc.date.accessioned | 2019-03-12T11:56:23Z | - |
dc.date.available | 2019-03-12T11:56:23Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 2213-6711 | - |
dc.identifier.uri | http://hdl.handle.net/2445/130119 | - |
dc.description.abstract | Taxanes are a mainstay of treatment for breast cancer, but resistance often develops followed by metastatic disease and mortality. Aiming to reveal the mechanisms underlying taxane resistance, we used breast cancer patient-derived orthoxenografts (PDX). Mimicking clinical behavior, triple-negative breast tumors (TNBCs) from PDX models were more sensitive to docetaxel than luminal tumors, but they progressively acquired resistance upon continuous drug administration. Mechanistically, we found that a CD49f+ chemoresistant population with tumor-initiating ability is present in sensitive tumors and expands during the acquisition of drug resistance. In the absence of the drug, the resistant CD49f+ population shrinks and taxane sensitivity is restored. We describe a transcriptional signature of resistance, predictive of recurrent disease after chemotherapy in TNBC. Together, these findings identify a CD49f+ population enriched in tumor-initiating ability and chemoresistance properties and evidence a drug holiday effect on the acquired resistance to docetaxel in triple-negative breast cancer. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.stemcr.2017.03.026 | - |
dc.relation.ispartof | Stem Cell Reports, 2017, vol. 8, num. 5, p. 1392-1407 | - |
dc.relation.uri | https://doi.org/10.1016/j.stemcr.2017.03.026 | - |
dc.rights | cc-by (c) Gómez Miragaya, Jorge et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Medicaments antineoplàstics | - |
dc.subject.classification | Ús terapèutic | - |
dc.subject.classification | Resistència als medicaments | - |
dc.subject.classification | Metabolisme | - |
dc.subject.classification | Integrines | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.other | Antineoplastic agents | - |
dc.subject.other | Therapeutic use | - |
dc.subject.other | Drug resistance | - |
dc.subject.other | Metabolism | - |
dc.subject.other | Integrins | - |
dc.subject.other | Breast cancer | - |
dc.title | Resistance to taxanes in triple negative breast cancer associates with the dynamics of a CD49f+ tumor initiating population | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 673483 | - |
dc.date.updated | 2019-03-12T11:56:23Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28457887 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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673483.pdf | 2.26 MB | Adobe PDF | View/Open |
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