Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/130480
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Duart Castells, Leticia | - |
dc.contributor.author | López Arnau, Raúl | - |
dc.contributor.author | Vizcaíno, Sonia | - |
dc.contributor.author | Camarasa García, Jordi | - |
dc.contributor.author | Pubill Sánchez, David | - |
dc.contributor.author | Escubedo Rafa, Elena | - |
dc.date.accessioned | 2019-03-18T11:32:20Z | - |
dc.date.available | 2020-02-05T06:10:14Z | - |
dc.date.issued | 2019-02-05 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | http://hdl.handle.net/2445/130480 | - |
dc.description.abstract | 3,4-Methylenedioxypyrovalerone (MDPV) acts as a dopamine transporter blocker and exerts powerful psychostimulant effects. In this study we aimed to investigate the bidirectional cross-sensitization between MDPV and cocaine, as well as to evaluate the role of the BDNF-TrkB signaling pathway in the development of locomotor sensitization to both drugs. Mice were treated with MDPV (1.5 mg/kg) or cocaine (10 or 15 mg/kg) once daily for 5 days. After withdrawal (10 days), animals were challenged with cocaine (8 mg/kg) or MDPV (1 mg/kg). For biochemical determinations, MDPV (1.5 mg/kg) or cocaine (15 mg/kg) were administered acutely or repeatedly, and BDNF, D3R and G9a transcription levels as well as pro- and mature BDNF protein levels were determined. Our results demonstrate that repeated administration of MDPV or cocaine sensitizes to cocaine and MDPV locomotor effects. After an acute or a repeated exposure to MDPV, cortical mRNA BDNF levels were increased, while a decrease in mBDNF protein levels in the nucleus accumbens 2 h after repeated exposure was evidenced. Interestingly, such decline was involved in the development of locomotor sensitization, thus the pretreatment with 7,8-dihydroxyflavone (10 mg/kg), a TrkB agonist, blocked the development of sensitization to MDPV but not to cocaine, for which no changes in the BDNF-TrkB signaling pathway were observed at early withdrawal. In conclusion, a bidirectional cross-sensitization between MDPV and cocaine was evidenced. Our findings suggest that decreased BDNF-TrkB signaling has an important role in the behavioral sensitization to MDPV, pointing TrkB modulation as a target to prevent MDPV sensitization Keywords: MDPV, Cocaine, Sensitization, BDNF, 7,8-Dihydroxyflavone | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.bcp.2019.02.004 | - |
dc.relation.ispartof | Biochemical Pharmacology, 2019, vol. 163, p. 84-93 | - |
dc.relation.uri | https://doi.org/10.1016/j.bcp.2019.02.004 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Dopamina | - |
dc.subject.classification | Cocaïna | - |
dc.subject.classification | Neurofarmacologia | - |
dc.subject.other | Dopamine | - |
dc.subject.other | Cocaine | - |
dc.subject.other | Neuropharmacology | - |
dc.title | 7,8-Dihydroxyflavone blocks the development of behavioral sensitization to MDPV, but not to cocaine: Differential role of the BDNF-TrkB pathway | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 685831 | - |
dc.date.updated | 2019-03-18T11:32:20Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
685831.pdf | 371.33 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License